Sign in or Register   Sign in or Register
  |  

Mouse Anti-MT2A (AA 1-61) Recombinant Antibody (CBFYM-2706) (CBMAB-M2896-FY)

This product is mouse antibody that recognizes MT2A. The antibody CBFYM-2706 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all MT2A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2706
Antibody Isotype
IgG2a, λ
Application
ELISA, IF, WB

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MDPNCSCAAG DSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCIC KGASDKCSCC A
Specificity
Human
Antibody Isotype
IgG2a, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-61

Target

Full Name
metallothionein 2A
Introduction
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer.
Entrez Gene ID
4502
UniProt ID
P02795
Alternative Names
Metallothionein 2A; Metallothionein-II; MT-II; MT-2; MT2; Metallothionein-2A; Metallothionein-2; CES1
Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Biological Process
Cellular copper ion homeostasis Source: ProtInc
Cellular response to cadmium ion Source: GO_Central
Cellular response to copper ion Source: GO_Central
Cellular response to erythropoietin Source: UniProtKB
Cellular response to interleukin-3 Source: UniProtKB
Cellular response to zinc ion Source: UniProtKB
Cellular zinc ion homeostasis Source: GO_Central
Detoxification of copper ion Source: GO_Central
Negative regulation of growth Source: UniProtKB
Cellular Location
Cytosol
Nucleus
Other locations
cytoplasm

Chen, R. F., Chen, P. M., Pan, C. S., Huang, C. C., & Chiang, E. P. I. (2023). Association of metallothionein 2A rs10636 with low mean corpuscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese. Scientific Reports, 13(1), 1292.

Wahyudi, L. D., Yu, S. H., & Cho, M. K. (2022). The effect of curcumin on the cadmium-induced mitochondrial apoptosis pathway by metallothionein 2A regulation. Life Sciences, 310, 121076.

Liu, X., Quan, J., Shen, Z., Zhang, Z., Chen, Z., Li, L., ... & Deng, X. (2022). Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer. Cancer Cell International, 22(1), 1-13.

Sung, H. C., Chang, K. S., Chen, S. T., Hsu, S. Y., Lin, Y. H., Hou, C. P., ... & Juang, H. H. (2022). Metallothionein 2A with Antioxidant and Antitumor Activity Is Upregulated by Caffeic Acid Phenethyl Ester in Human Bladder Carcinoma Cells. Antioxidants, 11(8), 1509.

Dias, A. M., de Mendonça, R. P., da Silva Kataoka, M. S., Jaeger, R. G., de Jesus Viana Pinheiro, J., & de Melo Alves Junior, S. (2022). Downregulation of metallothionein 2A reduces migration, invasion and proliferation activities in human squamous cell carcinoma cells. Molecular biology reports, 49(5), 3665-3674.

Shimizu, M., Koma, Y. I., Sakamoto, H., Tsukamoto, S., Kitamura, Y., Urakami, S., ... & Yokozaki, H. (2021). Metallothionein 2A expression in cancer-associated fibroblasts and cancer cells promotes esophageal squamous cell carcinoma progression. Cancers, 13(18), 4552.

Sekovanić, A., Jurasović, J., & Piasek, M. (2020). Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans. Archives of Industrial Hygiene and Toxicology, 71(1), 27.

Wang, J., Huang, P., Zhao, W., Ren, W., Ai, L., & Wu, L. (2020). Quantitative assessment of the association of polymorphisms in the metallothionein 2A gene with cancer risk. Journal of International Medical Research, 48(8), 0300060520947937.

Shokrzadeh, M., Mohammadpour, A., Ghassemi-Barghi, N., Hoseini, V., Abediankenari, S., & Tabari, Y. S. (2019). Metallothionein-2A (rs1610216&rs28366003) gene polymorphisms and the risk of stomach adenocarcinoma. Arquivos de Gastroenterologia, 56, 367-371.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MT2A (AA 1-61) Recombinant Antibody (CBFYM-2706)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare