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Mouse Anti-MTBP (N-terminus) Recombinant Antibody (CBFYM-2721) (CBMAB-M2914-FY)

This product is mouse antibody that recognizes MTBP. The antibody CBFYM-2721 can be used for immunoassay techniques such as: ELISA, WB.
See all MTBP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2721
Antibody Isotype
IgG1, k
Application
ELISA, WB

Basic Information

Immunogen
Synthetic peptide corresponding to aa667-812 from human MTBP at N-terminal, HIS6X-tagged
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.02 M Potassium phosphate, 0.15 M NaCl, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
MDM2 Binding Protein
Introduction
This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation.
Entrez Gene ID
27085
UniProt ID
Q96DY7
Alternative Names
MDM2 Binding Protein; MDM2 (Mouse Double Minute 2)-Binding Protein, 104kD; Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse) Binding Protein, 104kDa; Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein Binding Protein, 104kDa; Mdm2-Binding Protein; MDM2BP; HMTBP
Function
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity).

May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
Biological Process
Cell cycle Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of mitotic nuclear division Source: Ensembl
Protein localization to kinetochore Source: MGI
Regulation of protein ubiquitination Source: InterPro
Traversing start control point of mitotic cell cycle Source: GO_Central
Cellular Location
Chromatin
Kinetochore
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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