MTBP
This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]
Full Name
MDM2 Binding Protein
Function
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity).
May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
Biological Process
Cell cycle Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of mitotic nuclear division Source: Ensembl
Protein localization to kinetochore Source: MGI
Regulation of protein ubiquitination Source: InterPro
Traversing start control point of mitotic cell cycle Source: GO_Central
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of mitotic nuclear division Source: Ensembl
Protein localization to kinetochore Source: MGI
Regulation of protein ubiquitination Source: InterPro
Traversing start control point of mitotic cell cycle Source: GO_Central
Cellular Location
Chromatin
Kinetochore
Kinetochore
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Anti-MTBP antibodies
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Target: MTBP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A1198
Application*: WB
Target: MTBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1197
Application*: WB
Target: MTBP
Host: Mouse
Specificity: Human, Mouse
Clone: 2C1G6
Application*: WB
Target: MTBP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2721
Application*: E, WB
Target: MTBP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2720
Application*: WB, IP
Target: MTBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C1E11
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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