MTBP

This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]
Full Name
MDM2 Binding Protein
Function
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity).

May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
Biological Process
Cell cycle Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of mitotic nuclear division Source: Ensembl
Protein localization to kinetochore Source: MGI
Regulation of protein ubiquitination Source: InterPro
Traversing start control point of mitotic cell cycle Source: GO_Central
Cellular Location
Chromatin
Kinetochore
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Anti-MTBP antibodies

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Target: MTBP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A1198
Application*: WB
Target: MTBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1197
Application*: WB
Target: MTBP
Host: Mouse
Specificity: Human, Mouse
Clone: 2C1G6
Application*: WB
Target: MTBP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2721
Application*: E, WB
Target: MTBP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2720
Application*: WB, IP
Target: MTBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C1E11
Application*: WB
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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