MTBP

This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]

Full Name

MDM2 Binding Protein

Function

Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity).

May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.

Biological Process

Cell cycle Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of mitotic nuclear division Source: Ensembl
Protein localization to kinetochore Source: MGI
Regulation of protein ubiquitination Source: InterPro
Traversing start control point of mitotic cell cycle Source: GO_Central

Cellular Location

Chromatin
Kinetochore

Anti-MTBP antibodies

Mouse Anti-MTBP (N-terminus) Recombinant Antibody (CBFYM-2721) (CBMAB-M2914-FY)

Datasheet

SDS

Target: MTBP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2721

Application*: E, WB

Mouse Anti-MTBP (AA 1-425) Recombinant Antibody (CBFYM-2720) (CBMAB-M2913-FY)

Datasheet

SDS

Target: MTBP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2720

Application*: WB, IP

Mouse Anti-MTBP Recombinant Antibody (2C1E11) (CBMAB-M0125-FY)

Datasheet

SDS

Target: MTBP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C1E11

Application*: WB

Mouse Anti-MTBP Recombinant Antibody (A1198) (CBMAB-AP4877LY)

Datasheet

SDS

Target: MTBP

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: A1198

Application*: WB

Mouse Anti-MTBP Recombinant Antibody (A1197) (CBMAB-AP4876LY)

Datasheet

SDS

Target: MTBP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: A1197

Application*: WB

Recombinant Mouse Anti-MTBP Recombinant Antibody (2C1G6) (CBMAB-XB0838-YC)

Datasheet

SDS

Target: MTBP

Host: Mouse

Specificity: Human, Mouse

Clone: 2C1G6

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)