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Mouse Anti-MTTP Recombinant Antibody (CBFYM-2775) (CBMAB-M2968-FY)

This product is mouse antibody that recognizes MTTP. The antibody CBFYM-2775 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MTTP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2775
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN
Introduction
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
Entrez Gene ID
4547
UniProt ID
P55157
Alternative Names
Microsomal Triglyceride Transfer Protein; Microsomal Triglyceride Transfer Protein (Large Polypeptide, 88kDa); MTP; Microsomal Triglyceride Transfer Protein (Large Polypeptide, 88kD); Microsomal Triglyceride Transfer Protein Large Subunit; ABL
Function
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406, PubMed:16478722, PubMed:15897609, PubMed:8876250).

Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:8876250, PubMed:16478722).

May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).
Biological Process
Cholesterol homeostasis Source: GO_Central
Chylomicron assembly Source: Reactome
Circadian rhythm Source: Ensembl
Lipid metabolic process Source: ProtInc
Lipoprotein metabolic process Source: GO_Central
Lipoprotein transport Source: Ensembl
Low-density lipoprotein particle remodeling Source: Ensembl
Phospholipid transport Source: UniProtKB
Plasma lipoprotein particle assembly Source: UniProtKB
Protein lipidation Source: Ensembl
Protein secretion Source: UniProtKB
Response to calcium ion Source: Ensembl
Triglyceride metabolic process Source: Ensembl
Triglyceride transport Source: UniProtKB
Very-low-density lipoprotein particle assembly Source: Reactome
Cellular Location
Golgi apparatus
Endoplasmic reticulum
Note: Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785).
Involvement in disease
Abetalipoproteinemia (ABL):
An autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration.

Schneider, C. V., Hehl, L., Creasy, K. T., Vitali, C., Vell, M. S., Vujkovic, M., ... & Rader, D. J. (2023). A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids. Alimentary Pharmacology & Therapeutics, 58(2), 238-249.

Rajan, S., Hofer, P., Christiano, A., Stevenson, M., Ragolia, L., Villa-Cuesta, E., ... & Hussain, M. M. (2022). Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity. Metabolism, 137, 155331.

Anaganti, N., Chattopadhyay, A., Poirier, J. T., & Hussain, M. M. (2022). Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein. Journal of Lipid Research, 63(9).

Kong, A., Zhang, Y., Ning, B., Li, K., Ren, Z., Dai, S., ... & Shi, H. (2021). Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis. Chemico-Biological Interactions, 348, 109649.

Anaganti, N., Rajan, S., & Hussain, M. M. (2021). An improved assay to measure the phospholipid transfer activity of microsomal triglyceride transport protein. Journal of Lipid Research, 62.

Iqbal, J., Jahangir, Z., & Al-Qarni, A. A. (2020). Microsomal triglyceride transfer protein: from lipid metabolism to metabolic diseases. Lipid transfer in lipoprotein metabolism and cardiovascular disease, 37-52.

Wilson, M. H., Rajan, S., Danoff, A., White, R. J., Hensley, M. R., Quinlivan, V. H., ... & Farber, S. A. (2020). A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein. PLoS Genetics, 16(8), e1008941.

Biterova, E. I., Isupov, M. N., Keegan, R. M., Lebedev, A. A., Sohail, A. A., Liaqat, I., ... & Ruddock, L. W. (2019). The crystal structure of human microsomal triglyceride transfer protein. Proceedings of the National Academy of Sciences, 116(35), 17251-17260.

Blom, D. J., Raal, F. J., Santos, R. D., & Marais, A. D. (2019). Lomitapide and mipomersen—inhibiting microsomal triglyceride transfer protein (MTP) and apoB100 synthesis. Current atherosclerosis reports, 21, 1-10.

Khoury, E., Brisson, D., Roy, N., Tremblay, G., & Gaudet, D. (2019). Review of the long-term safety of lomitapide: a microsomal triglycerides transfer protein inhibitor for treating homozygous familial hypercholesterolemia. Expert opinion on drug safety, 18(5), 403-414.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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