Mouse Anti-MTTP (AA 91-288) Recombinant Antibody (CBFYM-2776) (CBMAB-M2969-FY)

Name: Mouse Anti-MTTP (AA 91-288) Recombinant Antibody (CBFYM-2776)
SKU: CBMAB-M2969-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2776

Application

Immunogen

Mouse MTP aa. 91-288

Specificity

Mouse, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.25 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 91-288

More Infomation

Target

Full Name

MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN

Introduction

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces.

Entrez Gene ID

Mouse	17777
Rat	310900

UniProt ID

Mouse	O08601
Rat	D4A1W8

Alternative Names

MTP; 1810043K16Rik

Function

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406, PubMed:16478722, PubMed:15897609, PubMed:8876250).

Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:8876250, PubMed:16478722).

May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).

Biological Process

Cholesterol homeostasis Source: GO_Central
Chylomicron assembly Source: Reactome
Circadian rhythm Source: Ensembl
Lipid metabolic process Source: ProtInc
Lipoprotein metabolic process Source: GO_Central
Lipoprotein transport Source: Ensembl
Low-density lipoprotein particle remodeling Source: Ensembl
Phospholipid transport Source: UniProtKB
Plasma lipoprotein particle assembly Source: UniProtKB
Protein lipidation Source: Ensembl
Protein secretion Source: UniProtKB
Response to calcium ion Source: Ensembl
Triglyceride metabolic process Source: Ensembl
Triglyceride transport Source: UniProtKB
Very-low-density lipoprotein particle assembly Source: Reactome

Cellular Location

Golgi apparatus
Endoplasmic reticulum
Note: Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785).

Involvement in disease

Abetalipoproteinemia (ABL):
An autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration.

Schneider, C. V., Hehl, L., Creasy, K. T., Vitali, C., Vell, M. S., Vujkovic, M., ... & Rader, D. J. (2023). A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids. Alimentary Pharmacology & Therapeutics, 58(2), 238-249.

Rajan, S., Hofer, P., Christiano, A., Stevenson, M., Ragolia, L., Villa-Cuesta, E., ... & Hussain, M. M. (2022). Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity. Metabolism, 137, 155331.

Anaganti, N., Chattopadhyay, A., Poirier, J. T., & Hussain, M. M. (2022). Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein. Journal of Lipid Research, 63(9).

Kong, A., Zhang, Y., Ning, B., Li, K., Ren, Z., Dai, S., ... & Shi, H. (2021). Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis. Chemico-Biological Interactions, 348, 109649.

Anaganti, N., Rajan, S., & Hussain, M. M. (2021). An improved assay to measure the phospholipid transfer activity of microsomal triglyceride transport protein. Journal of Lipid Research, 62.

Iqbal, J., Jahangir, Z., & Al-Qarni, A. A. (2020). Microsomal triglyceride transfer protein: from lipid metabolism to metabolic diseases. Lipid transfer in lipoprotein metabolism and cardiovascular disease, 37-52.

Wilson, M. H., Rajan, S., Danoff, A., White, R. J., Hensley, M. R., Quinlivan, V. H., ... & Farber, S. A. (2020). A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein. PLoS Genetics, 16(8), e1008941.

Biterova, E. I., Isupov, M. N., Keegan, R. M., Lebedev, A. A., Sohail, A. A., Liaqat, I., ... & Ruddock, L. W. (2019). The crystal structure of human microsomal triglyceride transfer protein. Proceedings of the National Academy of Sciences, 116(35), 17251-17260.

Blom, D. J., Raal, F. J., Santos, R. D., & Marais, A. D. (2019). Lomitapide and mipomersen—inhibiting microsomal triglyceride transfer protein (MTP) and apoB100 synthesis. Current atherosclerosis reports, 21, 1-10.

Khoury, E., Brisson, D., Roy, N., Tremblay, G., & Gaudet, D. (2019). Review of the long-term safety of lomitapide: a microsomal triglycerides transfer protein inhibitor for treating homozygous familial hypercholesterolemia. Expert opinion on drug safety, 18(5), 403-414.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-MTTP Recombinant Antibody (CBFYM-2775) (CAT#: CBMAB-M2968-FY)

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For research use only. Not intended for any clinical use.

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