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Mouse Anti-MUC12 (AA 1-919) Recombinant Antibody (CBFYM-2789) (CBMAB-M2982-FY)

This product is mouse antibody that recognizes MUC12. The antibody CBFYM-2789 can be used for immunoassay techniques such as: WB, IP.
See all MUC12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2789
Antibody Isotype
IgG1, k
Application
WB, IP

Basic Information

Immunogen
Recombinant human DNA Ligase I (aa 1-919) purified from baculovirus infected Sf9 cells
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-919

Target

Full Name
mucin 12, cell surface associated
Introduction
This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue.
Entrez Gene ID
10071
UniProt ID
Q9UKN1
Alternative Names
Mucin 12, Cell Surface Associated; Mucin-11; MUC-11; MUC-12; MUC11; Mucin 11; Mucin-12
Function
Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium.
Biological Process
Regulation of cell growth Source: UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 17-5380
Helical: 5381-5401
Cytoplasmic: 5402-5478

Cox, K. E., Liu, S., Lwin, T. M., Hoffman, R. M., Batra, S. K., & Bouvet, M. (2023). The mucin family of proteins: candidates as potential biomarkers for colon cancer. Cancers, 15(5), 1491.

Hebden, S., Jones, S., Al Amri, W., Maisey, T., Verghese, E., & Hughes, T. (2023). SP4. 5 Expression of trans-membrane mucins is associated with poor outcomes after chemotherapy in breast cancer. British Journal of Surgery, 110(Supplement_6), znad241-049.

Iranmanesh, H., Majd, A., Mojarad, E. N., Zali, M. R., & Hashemi, M. (2021). Investigating the Relationship between the Expression Level of Membrane-Bound Mucin (MUC12) and Clinicopathological Characterization of Colorectal Cancer. Archives of Advances in Biosciences, 12(1), 31-36.

Pham, E., Friedrich, M., Aeffner, F., Lutteropp, M., Mariano, N. F., Deegen, P., ... & Bailis, J. M. (2021). Preclinical assessment of a MUC12-targeted BiTE (bispecific t-cell engager) molecule. Molecular Cancer Therapeutics, 20(10), 1977-1987.

Jonckheere, N., Vincent, A., Neve, B., & Van Seuningen, I. (2021). Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(1), 188538.

Mandle, H. B., Jahan, F. A., Bostick, R. M., Baron, J. A., Barry, E. L., Yacoub, R., ... & Fedirko, V. (2019). Effects of supplemental calcium and vitamin D on tight‐junction proteins and mucin‐12 expression in the normal rectal mucosa of colorectal adenoma patients. Molecular carcinogenesis, 58(7), 1279-1290.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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