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Mouse Anti-MUC12 Recombinant Antibody (CBT3919) (V2LY-0625-LY1676)


See all MUC12 antibodies
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Tested Data
Mouse Anti-MUC12 Recombinant Antibody (CBT3919) (V2LY-0625-LY1676) in ELISA
Mouse Anti-MUC12 Recombinant Antibody (CBT3919) (V2LY-0625-LY1676) in ELISA
Mouse Anti-MUC12 Recombinant Antibody (CBT3919) (V2LY-0625-LY1676) in WB
Mouse Anti-MUC12 Recombinant Antibody (CBT3919) (V2LY-0625-LY1676) in WB
Mouse Anti-MUC12 Recombinant Antibody (CBT3919) (V2LY-0625-LY1676) in IF
Mouse Anti-MUC12 Recombinant Antibody (CBT3919) (V2LY-0625-LY1676) in IF
Mouse Anti-MUC12 Recombinant Antibody (CBT3919) (V2LY-0625-LY1676) in FC
Mouse Anti-MUC12 Recombinant Antibody (CBT3919) (V2LY-0625-LY1676) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3919
Antibody Isotype
IgG2b
Application
ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human MUC12 (AA: extra 371-592) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:50-1:200
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
mucin 12, cell surface associated
Entrez Gene ID
10071
UniProt ID
Q9UKN1
Function
Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium.
Biological Process
Regulation of cell growth Source: UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 17-5380
Helical: 5381-5401
Cytoplasmic: 5402-5478
More Infomation

Cox, K. E., Liu, S., Lwin, T. M., Hoffman, R. M., Batra, S. K., & Bouvet, M. (2023). The mucin family of proteins: candidates as potential biomarkers for colon cancer. Cancers, 15(5), 1491.

Hebden, S., Jones, S., Al Amri, W., Maisey, T., Verghese, E., & Hughes, T. (2023). SP4. 5 Expression of trans-membrane mucins is associated with poor outcomes after chemotherapy in breast cancer. British Journal of Surgery, 110(Supplement_6), znad241-049.

Iranmanesh, H., Majd, A., Mojarad, E. N., Zali, M. R., & Hashemi, M. (2021). Investigating the Relationship between the Expression Level of Membrane-Bound Mucin (MUC12) and Clinicopathological Characterization of Colorectal Cancer. Archives of Advances in Biosciences, 12(1), 31-36.

Pham, E., Friedrich, M., Aeffner, F., Lutteropp, M., Mariano, N. F., Deegen, P., ... & Bailis, J. M. (2021). Preclinical assessment of a MUC12-targeted BiTE (bispecific t-cell engager) molecule. Molecular Cancer Therapeutics, 20(10), 1977-1987.

Jonckheere, N., Vincent, A., Neve, B., & Van Seuningen, I. (2021). Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(1), 188538.

Mandle, H. B., Jahan, F. A., Bostick, R. M., Baron, J. A., Barry, E. L., Yacoub, R., ... & Fedirko, V. (2019). Effects of supplemental calcium and vitamin D on tight‐junction proteins and mucin‐12 expression in the normal rectal mucosa of colorectal adenoma patients. Molecular carcinogenesis, 58(7), 1279-1290.

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For research use only. Not intended for any clinical use.

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