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Mouse Anti-MUC16 Recombinant Antibody (CBYY-C2677) (CBMAB-C4118-YY)

This product is mouse antibody that recognizes MUC16. The antibody CBYY-C2677 can be used for immunoassay techniques such as: WB
See all MUC16 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2677
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 13942-14063 and 21117-21238 of human MUC16 (NP_078966) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Affinity purified
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mucin 16, Cell Surface Associated
Entrez Gene ID
UniProt ID
Alternative Names
NUF2, NDC80 Kinetochore Complex Component; Cell Division Cycle-Associated Protein 1; Cell Division Cycle Associated 1; Cancer/Testis Antigen 106; HNuf2R; HsNuf2; CDCA1;
Function
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Biological Process
Cell adhesion Source: UniProtKB
Cellular Location
Extracellular space
Plasma membrane
Cell membrane
Note: May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
Topology
Extracellular: 1-14451
Helical: 14452-14472
Cytoplasmic: 14473-14507
PTM
Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.
Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.
May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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