Mouse Anti-MYL4 (AA 1-197) Recombinant Antibody (CBFYM-0141) (CBMAB-M0162-FY)

Name: Mouse Anti-MYL4 (AA 1-197) Recombinant Antibody (CBFYM-0141)
SKU: CBMAB-M0162-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-0141

Antibody Isotype

IgG2a, k

Application

WB, ELISA

Basic Information

Immunogen

Recombinant human MYL4 (1-197aa) purified from E. coli

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-197

Target

Full Name

Myosin Light Chain 4

Introduction

Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Entrez Gene ID

4635

UniProt ID

P12829

Alternative Names

Myosin Light Chain 4; Myosin, Light Polypeptide 4, Alkali; Atrial, Embryonic; Myosin Light Chain 1, Embryonic Muscle/Atrial Isoform; Myosin, Light Chain 4, Alkali; Atrial, Embryonic; Myosin, Atrial/Fetal Muscle, Light Chain; Myosin Light Chain Alkali GT-1 Isoform

Function

Regulatory light chain of myosin. Does not bind calcium.

Biological Process

Cardiac muscle contraction Source: BHF-UCL
Positive regulation of ATP-dependent activity Source: BHF-UCL
Regulation of the force of heart contraction Source: BHF-UCL

Cellular Location

Cytoskeleton
myosin II
Cytosol
Other locations
A band

Involvement in disease

Atrial fibrillation, familial, 18 (ATFB18):
A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

More Infomation

References

Zhong, Y., Tang, K., Nattel, S., Zhai, M., Gong, S., Yu, Q., ... & Li, H. (2023). Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation. Redox Biology, 60, 102606.

Yu, Y., Fang, R., Jin, H., Wang, B., Gao, F., & He, B. (2023). Correlation between Serum Myosin Light Chain 4 Levels and Recurrence after Radiofrequency Ablation in Patients with Atrial Fibrillation. International Heart Journal, 64(4), 632-640.

Xu, X., Yu, Z., Ai, N., Liufu, S., Liu, X., Chen, B., ... & Yin, Y. (2023). Molecular Mechanism of MYL4 Regulation of Skeletal Muscle Development in Pigs. Genes, 14(6), 1267.

Zhong, Y., Tang, K., Li, H., Zhao, D., Kou, W., Xu, S., ... & Xu, Y. (2019). Rs4968309 in myosin light chain 4 (MYL4) associated with atrial fibrillation onset and predicts clinical outcomes after catheter ablation in atrial fibrillation patients without structural heart disease. Circulation Journal, 83(10), 1994-2001.

Wang, T. Y., Arking, D. E., Maleszewski, J. J., Fox-Talbot, K., Nieuwenhuis, T. O., Santhanam, L., ... & Halushka, M. K. (2019). Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex. Scientific reports, 9(1), 12681.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-MYL4 Recombinant Antibody (1A11-C8)

Mouse Anti-MYL4 (AA 2-197) Recombinant Antibody (CBFYM-2958)

Mouse Anti-MYL4 Recombinant Antibody (A1273)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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