MYL4

Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Myosin Light Chain 4

Regulatory light chain of myosin. Does not bind calcium.

Cardiac muscle contraction Source: BHF-UCL
Positive regulation of ATP-dependent activity Source: BHF-UCL
Regulation of the force of heart contraction Source: BHF-UCL

Cytoskeleton
myosin II
Cytosol
Other locations
A band

Atrial fibrillation, familial, 18 (ATFB18):
A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.