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MYL4

Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

Myosin Light Chain 4

Function

Regulatory light chain of myosin. Does not bind calcium.

Biological Process

Cardiac muscle contraction Source: BHF-UCL
Positive regulation of ATP-dependent activity Source: BHF-UCL
Regulation of the force of heart contraction Source: BHF-UCL

Cellular Location

Cytoskeleton
myosin II
Cytosol
Other locations
A band

Involvement in disease

Atrial fibrillation, familial, 18 (ATFB18):
A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

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Anti-MYL4 antibodies

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Mouse Anti-MYL4 Recombinant Antibody (A1273) (CBMAB-AP4956LY)

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Target: MYL4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: A1273

Application*: Dot blot, ELISA, WB

Mouse Anti-MYL4 Recombinant Antibody (A1273)

Mouse Anti-MYL4 Recombinant Antibody (1A11-C8) (CBMAB-A5727-LY)

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Target: MYL4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1A11-C8

Application*: WB, E

Mouse Anti-MYL4 Recombinant Antibody (1A11-C8)

Mouse Anti-MYL4 (AA 2-197) Recombinant Antibody (CBFYM-2958) (CBMAB-M3153-FY)

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Target: MYL4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-2958

Application*: P, WB

Mouse Anti-MYL4 (AA 2-197) Recombinant Antibody (CBFYM-2958)

Mouse Anti-MYL4 (AA 1-197) Recombinant Antibody (CBFYM-0141) (CBMAB-M0162-FY)

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Target: MYL4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-0141

Application*: WB, E

Mouse Anti-MYL4 (AA 1-197) Recombinant Antibody (CBFYM-0141)

Human MYL4 ELISA Kit (V2LY-0626-LY3811)

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Target: MYL4

Sensitivity: 0.024 ng/mL

Detection Range: 0.05-20 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Human MYL4 ELISA Kit

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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