Mouse Anti-NCALD Recombinant Antibody (A1298) (CBMAB-AP12533LY)

Name: Mouse Anti-NCALD Recombinant Antibody (A1298)
SKU: CBMAB-AP12533LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A1298

Application

ELISA, IHC, WB

Immunogen

Fusion protein of NCALD

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Neurocalcin Delta

Introduction

This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Entrez Gene ID

83988

UniProt ID

P61601

Alternative Names

Neurocalcin Delta; Neurocalcin-Delta;

Function

E-AB-27261

Biological Process

Calcium-mediated signaling Source: GO_Central
Regulation of systemic arterial blood pressure Source: Ensembl
Vesicle-mediated transport Source: UniProtKB

Cellular Location

Cytosol
Golgi apparatus
clathrin coat of trans-Golgi network vesicle

Meng, Y., Zhou, D., Luo, Y., Chen, J., & Li, H. (2024). An estrogen-regulated long non-coding RNA NCALD promotes luminal breast cancer proliferation by activating GRHL2. Cancer Cell International, 24(1), 49.

Muiños-Bühl, A., Rombo, R., Ling, K. K., Zilio, E., Rigo, F., Bennett, C. F., & Wirth, B. (2023). Long-term SMN-and Ncald-ASO combinatorial therapy in SMA mice and NCALD-ASO treatment in hiPSC-derived motor neurons show protective effects. International Journal of Molecular Sciences, 24(4), 4198.

Luo, D., Liang, Y., Wang, Y., Ye, F., Jin, Y., Li, Y., ... & Yang, Q. (2023). Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD. Breast Cancer Research, 25(1), 109.

Pan, S., Deng, Y., Fu, J., Zhang, Y., Zhang, Z., & Qin, X. (2022). N6‑methyladenosine upregulates miR‑181d‑5p in exosomes derived from cancer‑associated fibroblasts to inhibit 5‑FU sensitivity by targeting NCALD in colorectal cancer. International Journal of Oncology, 60(2), 1-17.

Zhang, Y. X., Zhang, X. T., Li, H. J., Zhou, T. F., Zhou, A. C., Zhong, Z. L., ... & Tong, J. C. (2021). Antidepressant-like effects of helicid on a chronic unpredictable mild stress-induced depression rat model: Inhibiting the IKK/IκBα/NF-κB pathway through NCALD to reduce inflammation. International immunopharmacology, 93, 107165.

Feng, L. Y., & Li, L. (2020). Low expression of NCALD is associated with chemotherapy resistance and poor prognosis in epithelial ovarian cancer. Journal of Ovarian Research, 13, 1-10.

Dong, C., Yin, F., Zhu, D., Cai, X., Chen, C., & Liu, X. (2020). NCALD affects drug resistance and prognosis by acting as a ceRNA of CX3CL1 in ovarian cancer. Journal of Cellular Biochemistry, 121(11), 4470-4483.

Torres-Benito, L., Schneider, S., Rombo, R., Ling, K. K., Grysko, V., Upadhyay, A., ... & Wirth, B. (2019). NCALD antisense oligonucleotide therapy in addition to nusinersen further ameliorates spinal muscular atrophy in mice. The American Journal of Human Genetics, 105(1), 221-230.

Song, Y., Zhang, W., He, X., Liu, X., Yang, P., Wang, J., ... & Yuan, X. (2019). High NCALD expression predicts poor prognosis of cytogenetic normal acute myeloid leukemia. Journal of translational medicine, 17(1), 1-12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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