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Mouse Anti-NCALD Recombinant Antibody (CF303) (CBMAB-FT198LY)

The product is antibody recognizes NCALD . The antibody CF303 immunoassay techniques such as: ELISA, WB, IHC.
See all NCALD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CF303
Antibody Isotype
IgG2a
Application
ELISA, WB, IHC

Basic Information

Immunogen
neurocalcin delta
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Neurocalcin Delta
Introduction
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Entrez Gene ID
83988
UniProt ID
P61601
Function
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.
Biological Process
Calcium-mediated signaling Source: GO_Central
Regulation of systemic arterial blood pressure Source: Ensembl
Vesicle-mediated transport Source: UniProtKB
Cellular Location
Cytosol
Golgi apparatus
clathrin coat of trans-Golgi network vesicle

Meng, Y., Zhou, D., Luo, Y., Chen, J., & Li, H. (2024). An estrogen-regulated long non-coding RNA NCALD promotes luminal breast cancer proliferation by activating GRHL2. Cancer Cell International, 24(1), 49.

Muiños-Bühl, A., Rombo, R., Ling, K. K., Zilio, E., Rigo, F., Bennett, C. F., & Wirth, B. (2023). Long-term SMN-and Ncald-ASO combinatorial therapy in SMA mice and NCALD-ASO treatment in hiPSC-derived motor neurons show protective effects. International Journal of Molecular Sciences, 24(4), 4198.

Luo, D., Liang, Y., Wang, Y., Ye, F., Jin, Y., Li, Y., ... & Yang, Q. (2023). Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD. Breast Cancer Research, 25(1), 109.

Pan, S., Deng, Y., Fu, J., Zhang, Y., Zhang, Z., & Qin, X. (2022). N6‑methyladenosine upregulates miR‑181d‑5p in exosomes derived from cancer‑associated fibroblasts to inhibit 5‑FU sensitivity by targeting NCALD in colorectal cancer. International Journal of Oncology, 60(2), 1-17.

Zhang, Y. X., Zhang, X. T., Li, H. J., Zhou, T. F., Zhou, A. C., Zhong, Z. L., ... & Tong, J. C. (2021). Antidepressant-like effects of helicid on a chronic unpredictable mild stress-induced depression rat model: Inhibiting the IKK/IκBα/NF-κB pathway through NCALD to reduce inflammation. International immunopharmacology, 93, 107165.

Feng, L. Y., & Li, L. (2020). Low expression of NCALD is associated with chemotherapy resistance and poor prognosis in epithelial ovarian cancer. Journal of Ovarian Research, 13, 1-10.

Dong, C., Yin, F., Zhu, D., Cai, X., Chen, C., & Liu, X. (2020). NCALD affects drug resistance and prognosis by acting as a ceRNA of CX3CL1 in ovarian cancer. Journal of Cellular Biochemistry, 121(11), 4470-4483.

Torres-Benito, L., Schneider, S., Rombo, R., Ling, K. K., Grysko, V., Upadhyay, A., ... & Wirth, B. (2019). NCALD antisense oligonucleotide therapy in addition to nusinersen further ameliorates spinal muscular atrophy in mice. The American Journal of Human Genetics, 105(1), 221-230.

Song, Y., Zhang, W., He, X., Liu, X., Yang, P., Wang, J., ... & Yuan, X. (2019). High NCALD expression predicts poor prognosis of cytogenetic normal acute myeloid leukemia. Journal of translational medicine, 17(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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