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Mouse Anti-NCOA6 Recombinant Antibody (2D7) (CBMAB-N1467-WJ)

This product is a Mouse antibody that recognizes NCOA6. The antibody 2D7 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all NCOA6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D7
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nuclear receptor coactivator 6
Introduction
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Entrez Gene ID
23054
UniProt ID
Q14686
Alternative Names
Nuclear Receptor Coactivator 6; Nuclear Receptor Coactivator RAP250; Peroxisome Proliferator-Activated Receptor Interacting Protein; Cancer-Amplified Transcriptional Coactivator ASC-2; Nuclear Receptor-Activating Protein, 250 KDa; Amplified In Breast Cancer Protein 3; Activating Signal Cointegrator-2; PPAR-Interacting Protein; NRC RAP250; RAP250; AIB3; PRIP;
Function
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Biological Process
Brain development Source: UniProtKB
Cellular response to DNA damage stimulus Source: MGI
DNA-templated transcription, initiation Source: UniProtKB
Heart development Source: UniProtKB
Histone H3-K4 methylation Source: ComplexPortal
Myeloid cell differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Response to hormone Source: UniProtKB
PTM
Phosphorylated by PRKDC.
Phosphorylation on Ser-884 leads to a strong decrease in binding to ESR1 and ESR2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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