Mouse Anti-NCOA6 Recombinant Antibody (E-12) (CBMAB-P0542-YC)

Name: Mouse Anti-NCOA6 Recombinant Antibody (E-12)
SKU: CBMAB-P0542-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

E-12

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

nuclear receptor coactivator 6

Introduction

NCOA6 is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors.

Entrez Gene ID

23054

UniProt ID

Q14686

Alternative Names

AIB3; ASC2; NRC; PRIP; RAP250; TRBP

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Biological Process

Brain development Source: UniProtKB
Cellular response to DNA damage stimulus Source: MGI
DNA-templated transcription, initiation Source: UniProtKB
Heart development Source: UniProtKB
Histone H3-K4 methylation Source: ComplexPortal
Myeloid cell differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Response to hormone Source: UniProtKB

PTM

Phosphorylated by PRKDC.
Phosphorylation on Ser-884 leads to a strong decrease in binding to ESR1 and ESR2.

Wang, X., Jia, Y., Xu, X., Hu, Y., Fan, G., Jing, D., ... & Peng, L. (2023). Nuclear receptor coactivator 6 (NCoA6) promotes cell proliferation, migration, and invasion in pancreatic cancer. Cancer Medicine, 12(17), 18425-18439.

Wang, R., He, Y., Wang, Y., & Xie, S. (2023). KMT2D Regulates the NCOA6/THRB Signal Axis through Epigenetic Modification to Promote the Migration and Invasion of Papillary Thyroid Cancer. Frontiers in Bioscience-Landmark, 28(1), 17.

Fang, Y., Xu, Y., Liao, W., Ji, T., Yu, L., Li, L., ... & Yang, D. (2022). Multi-omics Analyses and Machine Learning of NCOA6 Reveal Its Essential Role in Hepatocellular Carcinoma. Cancer Science.

Tong, Z., Liu, Y., Yu, X., Martinez, J. D., & Xu, J. (2019). The transcriptional co-activator NCOA6 promotes estrogen-induced GREB1 transcription by recruiting ERα and enhancing enhancer–promoter interactions. Journal of Biological Chemistry, 294(51), 19667-19682.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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