NCOA6

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases. [provided by RefSeq]

Full Name

nuclear receptor coactivator 6

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Biological Process

Brain development Source: UniProtKB
Cellular response to DNA damage stimulus Source: MGI
DNA-templated transcription, initiation Source: UniProtKB
Heart development Source: UniProtKB
Histone H3-K4 methylation Source: ComplexPortal
Myeloid cell differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Response to hormone Source: UniProtKB

PTM

Phosphorylated by PRKDC.
Phosphorylation on Ser-884 leads to a strong decrease in binding to ESR1 and ESR2.