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Mouse Anti-NDRG2 Recombinant Antibody (1D12) (CBMAB-N1580-WJ)

This product is a Mouse antibody that recognizes NDRG2. The antibody 1D12 can be used for immunoassay techniques such as: ELISA, WB.
See all NDRG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D12
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NDRG family member 2
Introduction
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Entrez Gene ID
57447
UniProt ID
Q9UN36
Alternative Names
NDRG Family Member 2; N-Myc Downstream-Regulated Gene 2 Protein; SYLD; N-Myc Downstream Regulator 2; NDR1-Related Protein NDR2; Cytoplasmic Protein Ndr1;
Function
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
Biological Process
Cell differentiation Source: UniProtKB-KW
Negative regulation of cytokine production Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of smooth muscle cell proliferation Source: Ensembl
Regulation of platelet-derived growth factor production Source: Ensembl
Regulation of vascular endothelial growth factor production Source: Ensembl
Signal transduction Source: GO_Central
Substantia nigra development Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Cytoplasm
Other locations
perinuclear region
growth cone
Note: In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).

Lee, S., Lee, A., Lim, J., & Lim, J. S. (2022). Regulation of tumor-associated macrophage (TAM) differentiation by NDRG2 expression in breast cancer cells. BMB reports, 55(2), 81.

Lee, A., Lim, S., Oh, J., Lim, J., Yang, Y., Lee, M. S., & Lim, J. S. (2021). NDRG2 expression in breast cancer cells downregulates PD-L1 expression and restores T cell proliferation in tumor-coculture. Cancers, 13(23), 6112.

Zhu, J., Yang, L. K., Wang, Q. H., Lin, W., Feng, Y., Xu, Y. P., ... & Wang, Y. H. (2020). NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1. Molecular Medicine Reports, 22(4), 3103-3110.

Yin, A., Guo, H., Tao, L., Cai, G., Wang, Y., Yao, L., ... & Li, Y. (2020). NDRG2 protects the brain from excitotoxicity by facilitating interstitial glutamate uptake. Translational Stroke Research, 11, 214-227.

Wei, M., Ma, Y., Shen, L., Xu, Y., Liu, L., Bu, X., ... & Zhang, J. (2020). NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis. EBioMedicine, 61.

Li, X., Wu, X., Luo, P., & Xiong, L. (2020). Astrocyte-specific NDRG2 gene: functions in the brain and neurological diseases. Cellular and Molecular Life Sciences, 77, 2461-2472.

Cheng, H., Zhang, L., Xia, F., Jin, L., Liu, S., Ren, H., ... & Tang, J. (2020). Astrocytic NDRG2 is critical in the maintenance of neuropathic pain. Brain, Behavior, and Immunity, 89, 300-313.

Wang, Y., Zhai, W. L., & Yang, Y. W. (2020). Association between NDRG2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats. European Review for Medical & Pharmacological Sciences, 24(7).

Chen, W., Peng, J., Ou, Q., Wen, Y., Jiang, W., Deng, Y., ... & Fang, Y. (2019). Expression of NDRG2 in human colorectal cancer and its association with prognosis. Journal of Cancer, 10(15), 3373.

Monfared, M. M., Zarei, M. A., Dehbidi, G. R., Behbahani, A. B., Arabsolghar, R., & Takhshid, M. A. (2019). NDRG2 regulates the expression of genes involved in epithelial mesenchymal transition of prostate cancer cells. Iranian Journal of Medical Sciences, 44(2), 118.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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