Mouse Anti-NDRG2 Recombinant Antibody (1D6) (CBMAB-N1581-WJ)

Name: Mouse Anti-NDRG2 Recombinant Antibody (1D6)
SKU: CBMAB-N1581-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1D6

Application

ELISA

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NDRG family member 2

Introduction

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

Entrez Gene ID

57447

UniProt ID

Q9UN36

Alternative Names

NDRG Family Member 2; N-Myc Downstream-Regulated Gene 2 Protein; SYLD; N-Myc Downstream Regulator 2; NDR1-Related Protein NDR2; Cytoplasmic Protein Ndr1;

Function

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Biological Process

Cell differentiation Source: UniProtKB-KW
Negative regulation of cytokine production Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of smooth muscle cell proliferation Source: Ensembl
Regulation of platelet-derived growth factor production Source: Ensembl
Regulation of vascular endothelial growth factor production Source: Ensembl
Signal transduction Source: GO_Central
Substantia nigra development Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Cytoplasm
Other locations
perinuclear region
growth cone
Note: In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).

Lee, S., Lee, A., Lim, J., & Lim, J. S. (2022). Regulation of tumor-associated macrophage (TAM) differentiation by NDRG2 expression in breast cancer cells. BMB reports, 55(2), 81.

Lee, A., Lim, S., Oh, J., Lim, J., Yang, Y., Lee, M. S., & Lim, J. S. (2021). NDRG2 expression in breast cancer cells downregulates PD-L1 expression and restores T cell proliferation in tumor-coculture. Cancers, 13(23), 6112.

Zhu, J., Yang, L. K., Wang, Q. H., Lin, W., Feng, Y., Xu, Y. P., ... & Wang, Y. H. (2020). NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1. Molecular Medicine Reports, 22(4), 3103-3110.

Yin, A., Guo, H., Tao, L., Cai, G., Wang, Y., Yao, L., ... & Li, Y. (2020). NDRG2 protects the brain from excitotoxicity by facilitating interstitial glutamate uptake. Translational Stroke Research, 11, 214-227.

Wei, M., Ma, Y., Shen, L., Xu, Y., Liu, L., Bu, X., ... & Zhang, J. (2020). NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis. EBioMedicine, 61.

Li, X., Wu, X., Luo, P., & Xiong, L. (2020). Astrocyte-specific NDRG2 gene: functions in the brain and neurological diseases. Cellular and Molecular Life Sciences, 77, 2461-2472.

Cheng, H., Zhang, L., Xia, F., Jin, L., Liu, S., Ren, H., ... & Tang, J. (2020). Astrocytic NDRG2 is critical in the maintenance of neuropathic pain. Brain, Behavior, and Immunity, 89, 300-313.

Wang, Y., Zhai, W. L., & Yang, Y. W. (2020). Association between NDRG2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats. European Review for Medical & Pharmacological Sciences, 24(7).

Chen, W., Peng, J., Ou, Q., Wen, Y., Jiang, W., Deng, Y., ... & Fang, Y. (2019). Expression of NDRG2 in human colorectal cancer and its association with prognosis. Journal of Cancer, 10(15), 3373.

Monfared, M. M., Zarei, M. A., Dehbidi, G. R., Behbahani, A. B., Arabsolghar, R., & Takhshid, M. A. (2019). NDRG2 regulates the expression of genes involved in epithelial mesenchymal transition of prostate cancer cells. Iranian Journal of Medical Sciences, 44(2), 118.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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