NDRG2

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq]

Full Name

NDRG family member 2

Function

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Biological Process

Cell differentiation Source: UniProtKB-KW
Negative regulation of cytokine production Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of smooth muscle cell proliferation Source: Ensembl
Regulation of platelet-derived growth factor production Source: Ensembl
Regulation of vascular endothelial growth factor production Source: Ensembl
Signal transduction Source: GO_Central
Substantia nigra development Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Cytoplasm
Other locations
perinuclear region
growth cone
Note: In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).