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Mouse Anti-NEGR1 Recombinant Antibody (2A8) (CBMAB-N1902-WJ)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
2A8
Application
ELISA
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
neuronal growth regulator 1
Introduction
May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
Entrez Gene ID
257194
UniProt ID
Q7Z3B1
Alternative Names
Neuronal Growth Regulator 1; IgLON Family Member 4; A Kindred Of IgLON; Neurotractin; IGLON4; DMML2433; KILON; Ntra;
Function
May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
Biological Process
Brain development Source: Ensembl
Cell-cell adhesion Source: Ensembl
Feeding behavior Source: Ensembl
Locomotory behavior Source: Ensembl
Positive regulation of neuron projection development Source: Ensembl
Regulation of synapse assembly Source: Ensembl
Cellular Location
Cell membrane

Pischedda, F., Ghirelli, A., Tripathi, V., & Piccoli, G. (2023). Negr1-Derived Peptides Trigger ALK Degradation and Halt Neuroblastoma Progression In Vitro and In Vivo. Pharmaceutics, 15(9), 2307.

Qiu, L., He, J., Chen, H., Xu, X., & Tao, Y. (2022). CircDLGAP4 overexpression relieves oxygen-glucose deprivation-induced neuronal injury by elevating NEGR1 through sponging miR-503-3p. Journal of Molecular Histology, 53(2), 321-332.

Kaare, M., Mikheim, K., Lilleväli, K., Kilk, K., Jagomäe, T., Leidmaa, E., ... & Philips, M. A. (2021). High-fat diet induces pre-diabetes and distinct sex-specific metabolic alterations in negr1-deficient mice. Biomedicines, 9(9), 1148.

Yan, Y., Chen, L., Zhou, J., & Xie, L. (2020). SNHG12 inhibits oxygen‑glucose deprivation‑induced neuronal apoptosis via the miR‑181a‑5p/NEGR1 axis. Molecular Medicine Reports, 22(5), 3886-3894.

Wang, X., Cheng, W., Zhu, J., Yin, H., Chang, S., Yue, W., & Yu, H. (2020). Integrating genome-wide association study and expression quantitative trait loci data identifies NEGR1 as a causal risk gene of major depression disorder. Journal of affective disorders, 265, 679-686.

Dong, Y., Fan, X., Wang, Z., Zhang, L., & Guo, S. (2020). Circ_HECW2 functions as a miR-30e-5p sponge to regulate LPS-induced endothelial-mesenchymal transition by mediating NEGR1 expression. Brain Research, 1748, 147114.

Carboni, L., Pischedda, F., Piccoli, G., Lauria, M., Musazzi, L., Popoli, M., ... & Domenici, E. (2020). Depression-associated gene Negr1-Fgfr2 pathway is altered by antidepressant treatment. Cells, 9(8), 1818.

Breton, E., Gagné-Ouellet, V., Thibeault, K., Guérin, R., Van Lieshout, R., Perron, P., ... & Bouchard, L. (2020). Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children. Epigenetics, 15(3), 323-335.

Singh, K., Jayaram, M., Kaare, M., Leidmaa, E., Jagomäe, T., Heinla, I., ... & Vasar, E. (2019). Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. Scientific reports, 9(1), 5457.

Noh, K., Lee, H., Choi, T. Y., Joo, Y., Kim, S. J., Kim, H., ... & Lee, S. J. (2019). Negr1 controls adult hippocampal neurogenesis and affective behaviors. Molecular psychiatry, 24(8), 1189-1205.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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