Mouse Negr1 ELISA Kit (V2LY-0626-LY2763)

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Tested Data
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.009 ng/mL
Detection Range
0.02-3.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
37.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
neuronal growth regulator 1
Function
May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
Biological Process
Brain development Source: Ensembl
Cell-cell adhesion Source: Ensembl
Feeding behavior Source: Ensembl
Locomotory behavior Source: Ensembl
Positive regulation of neuron projection development Source: Ensembl
Regulation of synapse assembly Source: Ensembl
Cellular Location
Cell membrane

Pischedda, F., Ghirelli, A., Tripathi, V., & Piccoli, G. (2023). Negr1-Derived Peptides Trigger ALK Degradation and Halt Neuroblastoma Progression In Vitro and In Vivo. Pharmaceutics, 15(9), 2307.

Qiu, L., He, J., Chen, H., Xu, X., & Tao, Y. (2022). CircDLGAP4 overexpression relieves oxygen-glucose deprivation-induced neuronal injury by elevating NEGR1 through sponging miR-503-3p. Journal of Molecular Histology, 53(2), 321-332.

Kaare, M., Mikheim, K., Lilleväli, K., Kilk, K., Jagomäe, T., Leidmaa, E., ... & Philips, M. A. (2021). High-fat diet induces pre-diabetes and distinct sex-specific metabolic alterations in negr1-deficient mice. Biomedicines, 9(9), 1148.

Yan, Y., Chen, L., Zhou, J., & Xie, L. (2020). SNHG12 inhibits oxygen‑glucose deprivation‑induced neuronal apoptosis via the miR‑181a‑5p/NEGR1 axis. Molecular Medicine Reports, 22(5), 3886-3894.

Wang, X., Cheng, W., Zhu, J., Yin, H., Chang, S., Yue, W., & Yu, H. (2020). Integrating genome-wide association study and expression quantitative trait loci data identifies NEGR1 as a causal risk gene of major depression disorder. Journal of affective disorders, 265, 679-686.

Dong, Y., Fan, X., Wang, Z., Zhang, L., & Guo, S. (2020). Circ_HECW2 functions as a miR-30e-5p sponge to regulate LPS-induced endothelial-mesenchymal transition by mediating NEGR1 expression. Brain Research, 1748, 147114.

Carboni, L., Pischedda, F., Piccoli, G., Lauria, M., Musazzi, L., Popoli, M., ... & Domenici, E. (2020). Depression-associated gene Negr1-Fgfr2 pathway is altered by antidepressant treatment. Cells, 9(8), 1818.

Breton, E., Gagné-Ouellet, V., Thibeault, K., Guérin, R., Van Lieshout, R., Perron, P., ... & Bouchard, L. (2020). Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children. Epigenetics, 15(3), 323-335.

Singh, K., Jayaram, M., Kaare, M., Leidmaa, E., Jagomäe, T., Heinla, I., ... & Vasar, E. (2019). Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. Scientific reports, 9(1), 5457.

Noh, K., Lee, H., Choi, T. Y., Joo, Y., Kim, S. J., Kim, H., ... & Lee, S. J. (2019). Negr1 controls adult hippocampal neurogenesis and affective behaviors. Molecular psychiatry, 24(8), 1189-1205.

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For research use only. Not intended for any clinical use.

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