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Mouse Anti-NEK3 Recombinant Antibody (2F8) (CBMAB-N1929-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F8
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NIMA Related Kinase 3
Introduction
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Entrez Gene ID
4752
UniProt ID
P51956
Alternative Names
NIMA Related Kinase 3; NIMA (Never In Mitosis Gene A)-Related Kinase 3; Never In Mitosis A-Related Kinase 3; Phosphorylase B Kinase Kinase; NimA-Related Protein Kinase 3; Hydroxyalkyl-Protein Kinase; Glycogen Synthase A Kinase;
Function
Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.
Biological Process
Cell division Source: UniProtKB-KW
Establishment of cell polarity Source: Ensembl
Mitotic cell cycle Source: UniProtKB
Neuron projection morphogenesis Source: Ensembl
Protein phosphorylation Source: UniProtKB
Regulation of tubulin deacetylation Source: Ensembl
Cellular Location
Cytoplasm
Other locations
axon
PTM
Phosphorylation at Thr-479 regulates its catalytic activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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