Human NEK3 ELISA Kit (V2LY-0626-LY3687)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.024 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
57.7 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
NIMA Related Kinase 3
Function
Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.
Biological Process
Cell division Source: UniProtKB-KW
Establishment of cell polarity Source: Ensembl
Mitotic cell cycle Source: UniProtKB
Neuron projection morphogenesis Source: Ensembl
Protein phosphorylation Source: UniProtKB
Regulation of tubulin deacetylation Source: Ensembl
Cellular Location
Cytoplasm
Other locations
axon
PTM
Phosphorylation at Thr-479 regulates its catalytic activity.

Zhang, Y., Chen, W., Zeng, W., Lu, Z., & Zhou, X. (2020). Biallelic loss of function NEK3 mutations deacetylate α-tubulin and downregulate NUP205 that predispose individuals to cilia-related abnormal cardiac left–right patterning. Cell Death & Disease, 11(11), 1005.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

NEK3 Matched Antibody Pair (791) (CAT#: APMAB-791LY)

Human Recombinant NEK3, Active protein, GST Tag (CAT#: V2LY-0526-LY5737)

Mouse Recombinant NEK3 protein, GST Tag (CAT#: V2LY-0526-LY8696)

Antibody Pairs

NEK3 Matched Antibody Pair (791) (CAT#: APMAB-791LY)

Related Products

Mouse Anti-NEK3 Recombinant Antibody (2F8) (CAT#: CBMAB-N1929-WJ)

NEK3 Matched Antibody Pair (791) (CAT#: APMAB-791LY)

Mouse Recombinant NEK3 protein, GST Tag (CAT#: V2LY-0526-LY8696)

Human Recombinant NEK3, Active protein, GST Tag (CAT#: V2LY-0526-LY5737)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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