Mouse Recombinant NEK3 protein, GST Tag (V2LY-0526-LY8696)

Name: Mouse Recombinant NEK3 protein, GST Tag
SKU: V2LY-0526-LY8696
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Mouse

Tag

GST Tag

Protein Construction

This product is Mouse Recombinant NEK3 protein, GST Tag consist of Amino Acid: 1-509 and predicts a molecular mass of 84.8 kDa.

Molecule Mass

84.8 kDa

Sequence

Amino Acid: 1-509

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

NIMA Related Kinase 3

Function

Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.

Biological Process

Cell division Source: UniProtKB-KW
Establishment of cell polarity Source: Ensembl
Mitotic cell cycle Source: UniProtKB
Neuron projection morphogenesis Source: Ensembl
Protein phosphorylation Source: UniProtKB
Regulation of tubulin deacetylation Source: Ensembl

Cellular Location

Cytoplasm
Other locations
axon

PTM

Phosphorylation at Thr-479 regulates its catalytic activity.

Zhang, Y., Chen, W., Zeng, W., Lu, Z., & Zhou, X. (2020). Biallelic loss of function NEK3 mutations deacetylate α-tubulin and downregulate NUP205 that predispose individuals to cilia-related abnormal cardiac left–right patterning. Cell Death & Disease, 11(11), 1005.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

NEK3 Matched Antibody Pair (791) (CAT#: APMAB-791LY)

Human Recombinant NEK3, Active protein, GST Tag (CAT#: V2LY-0526-LY5737)

Antibody Pairs

NEK3 Matched Antibody Pair (791) (CAT#: APMAB-791LY)

Related Products

Human Recombinant NEK3, Active protein, GST Tag (CAT#: V2LY-0526-LY5737)

NEK3 Matched Antibody Pair (791) (CAT#: APMAB-791LY)

Mouse Anti-NEK3 Recombinant Antibody (2F8) (CAT#: CBMAB-N1929-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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