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Mouse Anti-NELL2 Recombinant Antibody (CBWJN-1325) (CBMAB-N1961-WJ)

This product is a Mouse antibody that recognizes NELL2. The antibody CBWJN-1325 can be used for immunoassay techniques such as: ELISA.
See all NELL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1325
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neural EGFL Like 2
Introduction
The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]
Entrez Gene ID
4753
UniProt ID
Q99435
Alternative Names
Neural EGFL Like 2; NEL-Like Protein 2; NRP2; Protein Kinase C-Binding Protein NELL2; Neural Epidermal Growth Factor-Like 2; NEL-Related Protein 2; Nel-Related Protein 2; Nel (Chicken)-Like 2; NEL-Like 2 (Chicken);
Function
Required for neuron survival through the modulation of MAPK pathways (By similarity).

Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).
Biological Process
Fertilization Source: UniProtKB
Neuron cellular homeostasis Source: UniProtKB
Cellular Location
Secreted

Kiyozumi, D. (2024). Expression of NELL2/NICOL-ROS1 lumicrine signaling-related molecules in the human male reproductive tract. Reproductive Biology and Endocrinology, 22(1), 3.

Ha, C. M., Kim, D. H., Lee, T. H., Kim, H. R., Choi, J., Kim, Y., ... & Lee, B. J. (2022). Transcriptional regulatory role of NELL2 in preproenkephalin gene expression. Molecules and cells, 45(8), 537.

Kiyozumi, D. (2022). The molecular mechanisms of mammalian sperm maturation regulated by NELL2-ROS1 lumicrine signaling. The Journal of Biochemistry, 172(6), 341-346.

Wang, Y., Li, M., Zhang, L., Chen, Y., & Zhang, S. (2021). m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer. Molecular Therapy-Oncolytics, 21, 367-376.

Jayabal, P., Zhou, F., Lei, X., Ma, X., Blackman, B., Weintraub, S. T., ... & Shiio, Y. (2021). NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth. Cell reports, 36(1).

Liu, J., Liu, D., Zhang, X., Li, Y., Fu, X., He, W., ... & Zhang, X. (2021). NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia. Clinical Science, 135(13), 1591-1608.

Tong, L., Zhang, W., Qu, B., Zhang, F., Wu, Z., Shi, J., ... & Wang, Z. (2021). The tRNA-derived fragment-3017A promotes metastasis by inhibiting NELL2 in human gastric cancer. Frontiers in Oncology, 10, 570916.

Kiyozumi, D., Noda, T., Yamaguchi, R., Tobita, T., Matsumura, T., Shimada, K., ... & Ikawa, M. (2020). NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science, 368(6495), 1132-1135.

Pak, J. S., DeLoughery, Z. J., Wang, J., Acharya, N., Park, Y., Jaworski, A., & Özkan, E. (2020). NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance. Nature Communications, 11(1), 1489.

Taroc, E. Z. M., Lin, J. M., Tulloch, A. J., Jaworski, A., & Forni, P. E. (2019). GnRH-1 neural migration from the nose to the brain is independent from Slit2, Robo3 and NELL2 signaling. Frontiers in Cellular Neuroscience, 13, 70.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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