NELL2

The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]

Neural EGFL Like 2

Required for neuron survival through the modulation of MAPK pathways (By similarity).

Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).

Fertilization Source: UniProtKB
Neuron cellular homeostasis Source: UniProtKB

Secreted