Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-NFIL3 Recombinant Antibody (A1339) (CBMAB-AP12625LY)


See all NFIL3 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
A1339
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Fusion Protein of NFIL3
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction
The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
Entrez Gene ID
4783
UniProt ID
Q16649
Alternative Names
Nuclear Factor, Interleukin 3 Regulated; Interleukin-3 Promoter Transcriptional Activator; Transcriptional Activator NF-IL3A; Interleukin-3-Binding Protein 1; E4 Promoter-Binding Protein 4; IL3BP1;
Function
E-AB-27747
Biological Process
Cellular response to interleukin-4IEA:Ensembl
Circadian rhythmManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Natural killer cell differentiationISS:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:GO_Central
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase II2 PublicationsIC:ComplexPortal
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
More Infomation

Chen, S., Lei, M., Liu, K., & Min, J. (2024). Structural basis for specific DNA sequence recognition by the transcription factor NFIL3. Journal of Biological Chemistry, 105776.

Park, J., Cho, Y., Yang, D., Yang, H., Lee, D., Kubo, M., & Kang, S. J. (2024). The transcription factor NFIL3/E4BP4 regulates the developmental stage–specific acquisition of basophil function. Journal of Allergy and Clinical Immunology, 153(1), 132-145.

Zeng, G. G., Zhou, J., Jiang, W. L., Yu, J., Nie, G. Y., Li, J., ... & Tang, C. K. (2023). A potential role of NFIL3 in atherosclerosis. Current problems in cardiology, 102096.

Yang, W., Li, J., Zhang, M., Yu, H., Zhuang, Y., Zhao, L., ... & Li, X. (2022). Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription. Journal of Experimental & Clinical Cancer Research, 41(1), 67.

Zhuo, H., & Liu, J. (2022). Nuclear Factor Interleukin 3 (NFIL3) Participates in regulation of the NF-ΚB-mediated inflammation and antioxidant system in Litopenaeus vannamei under ammonia-n stress. Fish & Shellfish Immunology, 131, 1192-1205.

Kubo, M. (2020). Diurnal rhythmicity programs of microbiota and transcriptional oscillation of circadian regulator, NFIL3. Frontiers in Immunology, 11, 552188.

Hariri, H., Pellicelli, M., & St-Arnaud, R. (2020). Nfil3, a target of the NACA transcriptional coregulator, affects osteoblast and osteocyte gene expression differentially. Bone, 141, 115624.

Bagadia, P., Huang, X., Liu, T. T., Durai, V., Grajales-Reyes, G. E., Nitschké, M., ... & Murphy, K. M. (2019). An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development. Nature immunology, 20(9), 1174-1185.

Kim, H. S., Sohn, H., Jang, S. W., & Lee, G. R. (2019). The transcription factor NFIL3 controls regulatory T-cell function and stability. Experimental & molecular medicine, 51(7), 1-15.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NFIL3 Recombinant Antibody (A1339)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry