Mouse Anti-NFIL3 Recombinant Antibody (A1339) (CBMAB-AP12625LY)

Name: Mouse Anti-NFIL3 Recombinant Antibody (A1339)
SKU: CBMAB-AP12625LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A1339

Application

ELISA, WB

Immunogen

Fusion Protein of NFIL3

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Nuclear Factor, Interleukin 3 Regulated

Introduction

The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

Entrez Gene ID

4783

UniProt ID

Q16649

Alternative Names

Nuclear Factor, Interleukin 3 Regulated; Interleukin-3 Promoter Transcriptional Activator; Transcriptional Activator NF-IL3A; Interleukin-3-Binding Protein 1; E4 Promoter-Binding Protein 4; IL3BP1;

Function

E-AB-27747

Biological Process

Cellular response to interleukin-4IEA:Ensembl
Circadian rhythmManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Natural killer cell differentiationISS:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:GO_Central
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase II2 PublicationsIC:ComplexPortal
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus

Chen, S., Lei, M., Liu, K., & Min, J. (2024). Structural basis for specific DNA sequence recognition by the transcription factor NFIL3. Journal of Biological Chemistry, 105776.

Park, J., Cho, Y., Yang, D., Yang, H., Lee, D., Kubo, M., & Kang, S. J. (2024). The transcription factor NFIL3/E4BP4 regulates the developmental stage–specific acquisition of basophil function. Journal of Allergy and Clinical Immunology, 153(1), 132-145.

Zeng, G. G., Zhou, J., Jiang, W. L., Yu, J., Nie, G. Y., Li, J., ... & Tang, C. K. (2023). A potential role of NFIL3 in atherosclerosis. Current problems in cardiology, 102096.

Yang, W., Li, J., Zhang, M., Yu, H., Zhuang, Y., Zhao, L., ... & Li, X. (2022). Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription. Journal of Experimental & Clinical Cancer Research, 41(1), 67.

Zhuo, H., & Liu, J. (2022). Nuclear Factor Interleukin 3 (NFIL3) Participates in regulation of the NF-ΚB-mediated inflammation and antioxidant system in Litopenaeus vannamei under ammonia-n stress. Fish & Shellfish Immunology, 131, 1192-1205.

Kubo, M. (2020). Diurnal rhythmicity programs of microbiota and transcriptional oscillation of circadian regulator, NFIL3. Frontiers in Immunology, 11, 552188.

Hariri, H., Pellicelli, M., & St-Arnaud, R. (2020). Nfil3, a target of the NACA transcriptional coregulator, affects osteoblast and osteocyte gene expression differentially. Bone, 141, 115624.

Bagadia, P., Huang, X., Liu, T. T., Durai, V., Grajales-Reyes, G. E., Nitschké, M., ... & Murphy, K. M. (2019). An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development. Nature immunology, 20(9), 1174-1185.

Kim, H. S., Sohn, H., Jang, S. W., & Lee, G. R. (2019). The transcription factor NFIL3 controls regulatory T-cell function and stability. Experimental & molecular medicine, 51(7), 1-15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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