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Mouse Anti-NFIX Antibody (2D3) (CBMAB-0725-YC)

Provided herein are mouse monoclonal antibodies against Human NFIX. The antibody clone 2D3 can be used for immunoassay techniques, such as IP and MA.
See all NFIX antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D3
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NFIX
Introduction
NFIX (nuclear factor 1 X-type) is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. NFIX can also stimulate adenovirus replication in vitro.
Entrez Gene ID
UniProt ID
Alternative Names
CTF; NF1A; NF1-X; MRSHSS; NF-I/X; SOTOS2
Function
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Biological Process
DNA replicationIEA:UniProtKB-KW
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Involvement in disease
Sotos syndrome 2 (SOTOS2):
A form of Sotos syndrome, a childhood overgrowth syndrome characterized by prenatal and postnatal overgrowth, developmental delay, mental retardation, advanced bone age, and abnormal craniofacial morphology. SOTOS2 patients have macrocephaly, long narrow face, high forehead, slender habitus, scoliosis, and unusual behavior characterized especially by anxiety.
Marshall-Smith syndrome (MRSHSS):
A distinct malformation syndrome characterized by accelerated skeletal maturation, relative failure to thrive, respiratory difficulties, mental retardation, and unusual facies, including prominent forehead, shallow orbits, blue sclerae, depressed nasal bridge, and micrognathia. Additional skeletal findings include long and thin tubular bones, broad middle phalanges with relatively narrow distal phalanges, and scoliosis.

Ge, R., Wang, C., Liu, J., Jiang, H., Jiang, X., & Liu, Z. (2023). A novel tumor-promoting role for nuclear factor IX in glioblastoma is mediated through transcriptional activation of GINS1. Molecular Cancer Research, 21(3), 189-198.

Pan, D., Zhong, J., Zhang, J., Dong, H., Zhao, D., Zhang, H., & Yao, B. (2023). Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation. Gene, 881, 147620.

Kooblall, K. G., Stevenson, M., Stewart, M., Harris, L., Zalucki, O., Dewhurst, H., ... & Thakker, R. V. (2023). A Mouse Model with a Frameshift Mutation in the Nuclear Factor I/X (NFIX) Gene Has Phenotypic Features of Marshall‐Smith Syndrome. JBMR plus, 7(6), e10739.

Kawamoto, S., Hani, T., Fujita, K., Taya, Y., Sasaki, Y., Kudo, T., ... & Soeno, Y. (2023). Nuclear factor 1 X-type-associated regulation of myogenesis in developing mouse tongue. Journal of Oral Biosciences, 65(1), 88-96.

Walker, M. J. (2020). Characterization of Genome-Wide Binding of NUCLEAR-FACTOR IX in Hematopoietic Progenitor Cells.

Liu, Z., Ge, R., Zhou, J., Yang, X., Cheng, K. K. Y., Tao, J., ... & Mao, J. (2020). Nuclear factor IX promotes glioblastoma development through transcriptional activation of Ezrin. Oncogenesis, 9(4), 39.

Chaand, M., Fiore, C., Johnston, B. T., Moon, D. H., Carulli, J. P., & Shearstone, J. R. (2019). Chromatin accessibility mapping of primary erythroid cell populations leads to identification and validation of nuclear factor IX (NFIX) as a novel fetal hemoglobin (HbF) repressor. Blood, 134, 812.

Piper, M., Gronostajski, R., & Messina, G. (2019). Nuclear factor one X in development and disease. Trends in cell biology, 29(1), 20-30.

Priolo, M. (2019). Nuclear Factor One X Mice model for Malan syndrome: the less the better. EBioMedicine, 39, 15-16.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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