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Mouse Anti-NFKBIZ Recombinant Antibody (1E8) (CBMAB-N2317-WJ)

This product is a Mouse antibody that recognizes NFKBIZ. The antibody 1E8 can be used for immunoassay techniques such as: FC, WB.
See all NFKBIZ antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E8
Antibody Isotype
IgG1
Application
FC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.58 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NFKB Inhibitor Zeta
Introduction
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
64332
UniProt ID
Q9BYH8
Alternative Names
NFKB Inhibitor Zeta; IL-1 Inducible Nuclear Ankyrin-Repeat Protein; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Zeta; Molecule Possessing Ankyrin Repeats Induced By Lipopolysaccharide; NF-Kappa-B Inhibitor Zeta; I-Kappa-B-Zeta; IkappaBzeta;
Function
Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:16513645, PubMed:16622025).
Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:16513645).
Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:16513645).
Seems also to activate NF-kappa-B-mediated transcription (PubMed:16622025).
In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (PubMed:16622025).
Promotes transcription of LCN2 and DEFB4 (PubMed:16622025).
Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity).
Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity).
Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).
Biological Process
Inflammatory responseIEA:Ensembl
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of T-helper 17 cell differentiationISS:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
T cell receptor signaling pathwayISS:UniProtKB
Cellular Location
Nucleus
Aggregated in dot-like structures (PubMed:16513645).
Colocalizes with NCOR2 (PubMed:16513645).

Muromoto, R., Sato, A., Komori, Y., Nariya, K., Kitai, Y., Kashiwakura, J. I., & Matsuda, T. (2022). Regulation of NFKBIZ gene promoter activity by STAT3, C/EBPβ, and STAT1. Biochemical and Biophysical Research Communications, 613, 61-66.

Camblor, D. G., Miranda, D., Albaiceta, G. M., Amado-Rodríguez, L., Cuesta-Llavona, E., Vázquez-Coto, D., ... & Coto, E. (2022). Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patients. Human immunology, 83(8-9), 613-617.

Xu, T., Rao, T., Yu, W. M., Ning, J. Z., Yu, X., Zhu, S. M., ... & Cheng, F. (2021). Upregulation of NFKBIZ affects bladder cancer progression via the PTEN/PI3K/Akt signaling pathway. International Journal of Molecular Medicine, 47(6), 1-12.

Mandal, A., Kumbhojkar, N., Reilly, C., Dharamdasani, V., Ukidve, A., Ingber, D. E., & Mitragotri, S. (2020). Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations. Science advances, 6(30), eabb6049.

Kakiuchi, N., Yoshida, K., Uchino, M., Kihara, T., Akaki, K., Inoue, Y., ... & Ogawa, S. (2020). Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Nature, 577(7789), 260-265.

Liu, Z., Tang, C., He, L., Yang, D., Cai, J., Zhu, J., ... & Dong, Z. (2020). The negative feedback loop of NF-κB/miR-376b/NFKBIZ in septic acute kidney injury. JCI insight, 5(24).

Slowikowski, K., Nguyen, H. N., Noss, E. H., Simmons, D. P., Mizoguchi, F., Watts, G. F., ... & Raychaudhuri, S. (2020). CUX1 and IκBζ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts. Proceedings of the National Academy of Sciences, 117(10), 5532-5541.

Coto, E., Reguero, J. R., Avanzas, P., Pascual, I., Martín, M., Hevia, S., ... & Gómez, J. (2019). Gene variants in the NF-KB pathway (NFKB1, NFKBIA, NFKBIZ) and risk for early-onset coronary artery disease. Immunology letters, 208, 39-43.

Coto-Segura, P., González-Lara, L., Batalla, A., Eiris, N., Queiro, R., & Coto, E. (2019). NFKBIZ and Cw6 in adalimumab response among psoriasis patients: genetic association and alternative transcript analysis. Molecular Diagnosis & Therapy, 23, 627-633.

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For research use only. Not intended for any clinical use.

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