NFKBIZ

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

NFKB Inhibitor Zeta

Function

Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:16513645, PubMed:16622025).
Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:16513645).
Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:16513645).
Seems also to activate NF-kappa-B-mediated transcription (PubMed:16622025).
In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (PubMed:16622025).
Promotes transcription of LCN2 and DEFB4 (PubMed:16622025).
Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity).
Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity).
Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).

Biological Process

Inflammatory responseIEA:Ensembl
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of T-helper 17 cell differentiationISS:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
T cell receptor signaling pathwayISS:UniProtKB

Cellular Location

Nucleus
Aggregated in dot-like structures (PubMed:16513645).
Colocalizes with NCOR2 (PubMed:16513645).