Mouse Anti-NPAT Recombinant Antibody (CBWJN-0320) (CBMAB-N3098-WJ)

Name: Mouse Anti-NPAT Recombinant Antibody (CBWJN-0320)
SKU: CBMAB-N3098-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBWJN-0320

Application

Dot, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 1% BSA

Preservative

0.05% sodium azide

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

nuclear protein in the AT region

Introduction

Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.

Entrez Gene ID

4863

UniProt ID

Q14207

Alternative Names

Nuclear Protein, Coactivator Of Histone Transcription; Nuclear Protein Of The Ataxia Telangiectasia Mutated Locus; Nuclear Protein, Ataxia-Telangiectasia Locus; Nuclear Protein Of The ATM Locus; P220; E14;

Function

Biological Process

In utero embryonic developmentIEA:Ensembl
Ppositive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription involved in G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Nucleus, Cajal body
Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.

PTM

Phosphorylated at Ser-775, Ser-779, Ser-1100, Thr-1270 and Thr-1350 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-NPAT Recombinant Antibody (CBWJN-0328) (CAT#: CBMAB-N3099-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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