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Mouse Anti-NPAT Recombinant Antibody (CBWJN-0328) (CBMAB-N3099-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0328
Antibody Isotype
IgG2b
Application
WB, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nuclear protein in the AT region
Introduction
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.
Entrez Gene ID
4863
UniProt ID
Q14207
Alternative Names
Nuclear Protein, Coactivator Of Histone Transcription; Nuclear Protein Of The Ataxia Telangiectasia Mutated Locus; Nuclear Protein, Ataxia-Telangiectasia Locus; Nuclear Protein Of The ATM Locus; P220; E14;
Function
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.
Biological Process
In utero embryonic developmentIEA:Ensembl
Ppositive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription involved in G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Nucleus, Cajal body
Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.
PTM
Phosphorylated at Ser-775, Ser-779, Ser-1100, Thr-1270 and Thr-1350 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro.
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For research use only. Not intended for any clinical use.

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