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Mouse Anti-NPPC Recombinant Antibody (CBMAB-BR376LY)

The product is antibody recognizes NPPC. The antibody immunoassay techniques such as: IF, IHC, WB.
See all NPPC antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application
IF: 1:1000 dilution, IHC: 1:300-1:500 dilution, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
Full length human recombinant protein expressed in and purified from E. coli
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
5mM sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-type natriuretic peptide
Introduction
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
Entrez Gene ID
Human4880
Mouse18159
Rat114593
UniProt ID
HumanP23582
MouseQ61839
RatP55207
Alternative Names
C-type natriuretic peptide;CNP-22;CNP-29;CNP-53;Nppc;Cnp;
Function
CNP-22
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity).
May also be vasoactive and natriuretic (PubMed:1672777).
Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034).
Binds the clearance receptor NPR3 (PubMed:11533490).
Biological Process
cGMP biosynthetic processManual Assertion Based On ExperimentIDA:GO_Central
cGMP-mediated signalingIEA:Ensembl
Growth plate cartilage chondrocyte differentiationISS:UniProtKB
Growth plate cartilage chondrocyte proliferationISS:UniProtKB
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of collagen biosynthetic processIEA:Ensembl
Negative regulation of DNA biosynthetic processIEA:Ensembl
Negative regulation of meiotic cell cycleManual Assertion Based On ExperimentIDA:MGI
Negative regulation of oocyte maturationManual Assertion Based On ExperimentIDA:MGI
OssificationIEA:UniProtKB-KW
Positive regulation of cGMP-mediated signalingIEA:Ensembl
Positive regulation of osteoblast differentiationIEA:Ensembl
Post-embryonic developmentIEA:Ensembl
Protein foldingManual Assertion Based On ExperimentIDA:CAFA
Receptor guanylyl cyclase signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of multicellular organism growthIEA:Ensembl
Regulation of smooth muscle cell proliferationIEA:Ensembl
Reproductive processIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Secreted
PTM
CNP-22
Degraded by IDE (in vitro).

Gregory, J. M., Kraft, G., Farmer, B., Smith, M. S., LaNeve, D. C., Williams, P. E., ... & Coate, K. C. (2021). Insulin infusion is linked to increased NPPC expression in muscle and plasma C-type natriuretic peptide in male dogs. Journal of the Endocrine Society, 5(7), bvab088.

Moyes, A. J., Chu, S. M., Aubdool, A. A., Dukinfield, M. S., Margulies, K. B., Bedi Jr, K. C., ... & Hobbs, A. J. (2020). C-type natriuretic peptide co-ordinates cardiac structure and function. European heart journal, 41(9), 1006-1020.

Ueda, Y., Hirota, K., Yamauchi, I., Hakata, T., Yamashita, T., Fujii, T., ... & Inagaki, N. (2020). Is C-type natriuretic peptide regulated by a feedback loop? A study on systemic and local autoregulatory effect. PLoS One, 15(10), e0240023.

Prickett, T. C., & Espiner, E. A. (2020). Circulating products of C-type natriuretic peptide and links with organ function in health and disease. Peptides, 132, 170363.

Agrawal, V., Fortune, N., Yu, S., Fuentes, J., Shi, F., Nichols, D., ... & Hemnes, A. R. (2019). Natriuretic peptide receptor C contributes to disproportionate right ventricular hypertrophy in a rodent model of obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension. Pulmonary circulation, 9(4), 2045894019878599.

Mirczuk, S. M., Lessey, A. J., Catterick, A. R., Perrett, R. M., Scudder, C. J., Read, J. E., ... & Fowkes, R. C. (2019). Regulation and function of C-type natriuretic peptide (CNP) in gonadotrope-derived cell lines. Cells, 8(9), 1086.

Yang, J., Zhang, Y., Xu, X., Li, J., Yuan, F., Bo, S., ... & Zhang, M. (2019). Transforming growth factor-β is involved in maintaining oocyte meiotic arrest by promoting natriuretic peptide type C expression in mouse granulosa cells. Cell Death & Disease, 10(8), 558.

Xi, G., Wang, W., Fazlani, S. A., Yao, F., Yang, M., Hao, J., ... & Tian, J. (2019). C-type natriuretic peptide enhances mouse preantral follicle growth. Reproduction, 157(5), 445-455.

Liu, C., Sun, W., Zhuo, G., & Zhang, Z. (2019). Impacts of macrophage colony-stimulating factor (M-CSF) on the expression of natriuretic peptide precursor type C (NPPC) and regulation of meiotic resumption. Gynecological Endocrinology, 35(4), 320-323.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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