NPPC

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]

C-type natriuretic peptide

CNP-22
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity).
May also be vasoactive and natriuretic (PubMed:1672777).
Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034).
Binds the clearance receptor NPR3 (PubMed:11533490).

cGMP biosynthetic processManual Assertion Based On ExperimentIDA:GO_Central
cGMP-mediated signalingIEA:Ensembl
Growth plate cartilage chondrocyte differentiationISS:UniProtKB
Growth plate cartilage chondrocyte proliferationISS:UniProtKB
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of collagen biosynthetic processIEA:Ensembl
Negative regulation of DNA biosynthetic processIEA:Ensembl
Negative regulation of meiotic cell cycleManual Assertion Based On ExperimentIDA:MGI
Negative regulation of oocyte maturationManual Assertion Based On ExperimentIDA:MGI
OssificationIEA:UniProtKB-KW
Positive regulation of cGMP-mediated signalingIEA:Ensembl
Positive regulation of osteoblast differentiationIEA:Ensembl
Post-embryonic developmentIEA:Ensembl
Protein foldingManual Assertion Based On ExperimentIDA:CAFA
Receptor guanylyl cyclase signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of multicellular organism growthIEA:Ensembl
Regulation of smooth muscle cell proliferationIEA:Ensembl
Reproductive processIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl

Secreted

CNP-22
Degraded by IDE (in vitro).