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NPPC

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
Full Name
C-type natriuretic peptide
Function
CNP-22
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity).
May also be vasoactive and natriuretic (PubMed:1672777).
Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034).
Binds the clearance receptor NPR3 (PubMed:11533490).
Biological Process
cGMP biosynthetic processManual Assertion Based On ExperimentIDA:GO_Central
cGMP-mediated signalingIEA:Ensembl
Growth plate cartilage chondrocyte differentiationISS:UniProtKB
Growth plate cartilage chondrocyte proliferationISS:UniProtKB
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of collagen biosynthetic processIEA:Ensembl
Negative regulation of DNA biosynthetic processIEA:Ensembl
Negative regulation of meiotic cell cycleManual Assertion Based On ExperimentIDA:MGI
Negative regulation of oocyte maturationManual Assertion Based On ExperimentIDA:MGI
OssificationIEA:UniProtKB-KW
Positive regulation of cGMP-mediated signalingIEA:Ensembl
Positive regulation of osteoblast differentiationIEA:Ensembl
Post-embryonic developmentIEA:Ensembl
Protein foldingManual Assertion Based On ExperimentIDA:CAFA
Receptor guanylyl cyclase signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of multicellular organism growthIEA:Ensembl
Regulation of smooth muscle cell proliferationIEA:Ensembl
Reproductive processIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Secreted
PTM
CNP-22
Degraded by IDE (in vitro).
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Anti-NPPC antibodies

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Mouse Anti-NPPC Recombinant Antibody (CBMAB-BR376LY)

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Target: NPPC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Application*: IF, IHC, WB
Datasheet SDS

Mouse Anti-NPPC Recombinant Antibody (CBCNC-673) (CBMAB-C4040-CN)

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Target: NPPC
Host: Mouse
Specificity: Human
Clone: CBCNC-673
Application*: WB, IH, E
Datasheet SDS

Rat Anti-NPPC Recombinant Antibody (CBXC-1128) (CBMAB-C1394-CQ)

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Target: NPPC
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1128
Application*: WB
Datasheet SDS

Rat Anti-NPPC Recombinant Antibody (CBYY-C0034) (CBMAB-C0094-YY)

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Target: NPPC
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0034
Application*: IH, WB
Datasheet SDS

Rat Anti-NPPC Recombinant Antibody (8H204) (CBMAB-N3234-WJ)

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Target: NPPC
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: 8H204
Application*: E, WB
Datasheet SDS

Rat Anti-NPPC Recombinant Antibody (462608) (CBMAB-1629-CN)

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Target: NPPC
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: 462608
Application*: WB
Datasheet SDS

Rat Anti-NPPC Recombinant Antibody (347625) (CBMAB-1628-CN)

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Target: NPPC
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 347625
Application*: WB, IH
Datasheet SDS

Mouse Anti-NPPC Recombinant Antibody (CBLNC-162) (CBMAB-1627-CN)

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Target: NPPC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Dog, Mouse, Rabbit, Rat, Sheep
Clone: CBLNC-162
Application*: WB, E, IC, IH
Datasheet SDS

Mouse Anti-NPPC Recombinant Antibody (2E8) (CBMAB-1626-CN)

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Target: NPPC
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2E8
Application*: WB, E, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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