Mouse Anti-NPPC Recombinant Antibody (CBCNC-673) (CBMAB-C4040-CN)

Name: Mouse Anti-NPPC Recombinant Antibody (CBCNC-673)
SKU: CBMAB-C4040-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNC-673

Application

WB, IHC, ELISA

Immunogen

Reacts with human; Predicted to work with Mouse and Rat

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95%

More Infomation

Target

Full Name

C-type natriuretic peptide

Introduction

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]

Entrez Gene ID

4880

UniProt ID

P23582

Alternative Names

Natriuretic Peptide C; CNP2; Natriuretic Peptide Precursor Type C; Natriuretic Peptide Precursor C; C-Type Natriuretic Peptide; CNP;

Function

CNP-22
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity).
May also be vasoactive and natriuretic (PubMed:1672777).
Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034).
Binds the clearance receptor NPR3 (PubMed:11533490).

Biological Process

cGMP biosynthetic processManual Assertion Based On ExperimentIDA:GO_Central
cGMP-mediated signalingIEA:Ensembl
Growth plate cartilage chondrocyte differentiationISS:UniProtKB
Growth plate cartilage chondrocyte proliferationISS:UniProtKB
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of collagen biosynthetic processIEA:Ensembl
Negative regulation of DNA biosynthetic processIEA:Ensembl
Negative regulation of meiotic cell cycleManual Assertion Based On ExperimentIDA:MGI
Negative regulation of oocyte maturationManual Assertion Based On ExperimentIDA:MGI
OssificationIEA:UniProtKB-KW
Positive regulation of cGMP-mediated signalingIEA:Ensembl
Positive regulation of osteoblast differentiationIEA:Ensembl
Post-embryonic developmentIEA:Ensembl
Protein foldingManual Assertion Based On ExperimentIDA:CAFA
Receptor guanylyl cyclase signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of multicellular organism growthIEA:Ensembl
Regulation of smooth muscle cell proliferationIEA:Ensembl
Reproductive processIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl

Cellular Location

Secreted

PTM

CNP-22
Degraded by IDE (in vitro).

Gregory, J. M., Kraft, G., Farmer, B., Smith, M. S., LaNeve, D. C., Williams, P. E., ... & Coate, K. C. (2021). Insulin infusion is linked to increased NPPC expression in muscle and plasma C-type natriuretic peptide in male dogs. Journal of the Endocrine Society, 5(7), bvab088.

Moyes, A. J., Chu, S. M., Aubdool, A. A., Dukinfield, M. S., Margulies, K. B., Bedi Jr, K. C., ... & Hobbs, A. J. (2020). C-type natriuretic peptide co-ordinates cardiac structure and function. European heart journal, 41(9), 1006-1020.

Ueda, Y., Hirota, K., Yamauchi, I., Hakata, T., Yamashita, T., Fujii, T., ... & Inagaki, N. (2020). Is C-type natriuretic peptide regulated by a feedback loop? A study on systemic and local autoregulatory effect. PLoS One, 15(10), e0240023.

Prickett, T. C., & Espiner, E. A. (2020). Circulating products of C-type natriuretic peptide and links with organ function in health and disease. Peptides, 132, 170363.

Agrawal, V., Fortune, N., Yu, S., Fuentes, J., Shi, F., Nichols, D., ... & Hemnes, A. R. (2019). Natriuretic peptide receptor C contributes to disproportionate right ventricular hypertrophy in a rodent model of obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension. Pulmonary circulation, 9(4), 2045894019878599.

Mirczuk, S. M., Lessey, A. J., Catterick, A. R., Perrett, R. M., Scudder, C. J., Read, J. E., ... & Fowkes, R. C. (2019). Regulation and function of C-type natriuretic peptide (CNP) in gonadotrope-derived cell lines. Cells, 8(9), 1086.

Yang, J., Zhang, Y., Xu, X., Li, J., Yuan, F., Bo, S., ... & Zhang, M. (2019). Transforming growth factor-β is involved in maintaining oocyte meiotic arrest by promoting natriuretic peptide type C expression in mouse granulosa cells. Cell Death & Disease, 10(8), 558.

Xi, G., Wang, W., Fazlani, S. A., Yao, F., Yang, M., Hao, J., ... & Tian, J. (2019). C-type natriuretic peptide enhances mouse preantral follicle growth. Reproduction, 157(5), 445-455.

Liu, C., Sun, W., Zhuo, G., & Zhang, Z. (2019). Impacts of macrophage colony-stimulating factor (M-CSF) on the expression of natriuretic peptide precursor type C (NPPC) and regulation of meiotic resumption. Gynecological Endocrinology, 35(4), 320-323.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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