Sign in or Register   Sign in or Register
  |  

Rat Anti-NPR1 Recombinant Antibody (CBWJN-0542) (CBMAB-N3240-WJ)

This product is a Rat antibody that recognizes NPR1. The antibody CBWJN-0542 can be used for immunoassay techniques such as: ELISA, IHC.
See all NPR1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBWJN-0542
Antibody Isotype
IgG2a
Application
ELISA, IHC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, pH 7.4, 5% Trehalose
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NATRIURETIC PEPTIDE RECEPTOR 1
Introduction
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
Entrez Gene ID
18160
UniProt ID
P18293
Alternative Names
Natriuretic Peptide Receptor 1; Guanylate Cyclase A; Atrial Natriuretic Peptide Receptor Type A; Atrionatriuretic Peptide Receptor A; Natriuretic Peptide Receptor A; EC 4.6.1.2; ANPR-A; ANPRA; ANP-A; NPR-A;
Function
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Biological Process
Blood vessel diameter maintenance1 PublicationNAS:UniProtKB
Body fluid secretionManual Assertion Based On ExperimentTAS:UniProtKB
Cell surface receptor signaling pathway1 PublicationNAS:UniProtKB
cGMP biosynthetic processManual Assertion Based On ExperimentIDA:GO_Central
cGMP-mediated signalingIEA:Ensembl
Dopamine metabolic processIEA:Ensembl
Negative regulation of angiogenesisManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of cell growth1 PublicationNAS:UniProtKB
Negative regulation of smooth muscle cell proliferationIEA:Ensembl
Positive regulation of cGMP-mediated signalingIEA:Ensembl
Positive regulation of renal sodium excretionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of urine volumeManual Assertion Based On ExperimentTAS:UniProtKB
Receptor guanylyl cyclase signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of blood pressure1 PublicationNAS:UniProtKB
Regulation of vascular permeabilityManual Assertion Based On ExperimentTAS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 33-473
Helical: 474-494
Cytoplasmic: 495-1061
PTM
Phosphorylation of the protein kinase-like domain is required for full activation by ANP.

Sasahara, M., Kanda, M., Tanaka, C., Shimizu, D., Umeda, S., Takami, H., ... & Kodera, Y. (2024). Therapeutic antibody targeting natriuretic peptide receptor 1 inhibits gastric cancer growth via BCL‐2‐mediated intrinsic apoptosis. International Journal of Cancer, 154(7), 1272-1284.

Tokudome, T., Otani, K., Mao, Y., Jensen, L. J., Arai, Y., Miyazaki, T., ... & Nishimura, H. (2022). Endothelial natriuretic peptide receptor 1 play crucial role for acute and chronic blood pressure regulation by atrial natriuretic peptide. Hypertension, 79(7), 1409-1422.

Pandey, K. N. (2019). Genetic ablation and guanylyl cyclase/natriuretic peptide receptor-A: impact on the pathophysiology of cardiovascular dysfunction. International Journal of Molecular Sciences, 20(16), 3946.

Solinski, H. J., Dranchak, P., Oliphant, E., Gu, X., Earnest, T. W., Braisted, J., ... & Hoon, M. A. (2019). Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 11(500), eaav5464.

Periyasamy, R., Das, S., & Pandey, K. N. (2019). Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice. Peptides, 114, 17-28.

Vandenwijngaert, S., Ledsky, C. D., Lahrouchi, N., Khan, M. A., Wunderer, F., Ames, L., ... & CHARGE+ Exome Chip Blood Pressure Consortium, the CHD Exome+ Consortium, the Exome BP Consortium, the GoT2D Consortium, the T2D-GENES Consortium and the UK Biobank CardioMetabolic Consortium BP Working Group. (2019). Blood pressure-associated genetic variants in the natriuretic peptide receptor 1 gene modulate guanylate cyclase activity. Circulation: Genomic and Precision Medicine, 12(8), e002472.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-NPR1 Recombinant Antibody (CBWJN-0542)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare