Human NPR1 ELISA Kit (V2LY-0626-LY3664)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.047 ng/mL
Detection Range
0.1-35 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
118.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
NATRIURETIC PEPTIDE RECEPTOR 1
Function
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Biological Process
Blood vessel diameter maintenance1 PublicationNAS:UniProtKB
Body fluid secretionManual Assertion Based On ExperimentTAS:UniProtKB
Cell surface receptor signaling pathway1 PublicationNAS:UniProtKB
cGMP biosynthetic processManual Assertion Based On ExperimentIDA:GO_Central
cGMP-mediated signalingIEA:Ensembl
Dopamine metabolic processIEA:Ensembl
Negative regulation of angiogenesisManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of cell growth1 PublicationNAS:UniProtKB
Negative regulation of smooth muscle cell proliferationIEA:Ensembl
Positive regulation of cGMP-mediated signalingIEA:Ensembl
Positive regulation of renal sodium excretionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of urine volumeManual Assertion Based On ExperimentTAS:UniProtKB
Receptor guanylyl cyclase signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of blood pressure1 PublicationNAS:UniProtKB
Regulation of vascular permeabilityManual Assertion Based On ExperimentTAS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 33-473
Helical: 474-494
Cytoplasmic: 495-1061
PTM
Phosphorylation of the protein kinase-like domain is required for full activation by ANP.

Sasahara, M., Kanda, M., Tanaka, C., Shimizu, D., Umeda, S., Takami, H., ... & Kodera, Y. (2024). Therapeutic antibody targeting natriuretic peptide receptor 1 inhibits gastric cancer growth via BCL‐2‐mediated intrinsic apoptosis. International Journal of Cancer, 154(7), 1272-1284.

Tokudome, T., Otani, K., Mao, Y., Jensen, L. J., Arai, Y., Miyazaki, T., ... & Nishimura, H. (2022). Endothelial natriuretic peptide receptor 1 play crucial role for acute and chronic blood pressure regulation by atrial natriuretic peptide. Hypertension, 79(7), 1409-1422.

Pandey, K. N. (2019). Genetic ablation and guanylyl cyclase/natriuretic peptide receptor-A: impact on the pathophysiology of cardiovascular dysfunction. International Journal of Molecular Sciences, 20(16), 3946.

Solinski, H. J., Dranchak, P., Oliphant, E., Gu, X., Earnest, T. W., Braisted, J., ... & Hoon, M. A. (2019). Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 11(500), eaav5464.

Periyasamy, R., Das, S., & Pandey, K. N. (2019). Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice. Peptides, 114, 17-28.

Vandenwijngaert, S., Ledsky, C. D., Lahrouchi, N., Khan, M. A., Wunderer, F., Ames, L., ... & CHARGE+ Exome Chip Blood Pressure Consortium, the CHD Exome+ Consortium, the Exome BP Consortium, the GoT2D Consortium, the T2D-GENES Consortium and the UK Biobank CardioMetabolic Consortium BP Working Group. (2019). Blood pressure-associated genetic variants in the natriuretic peptide receptor 1 gene modulate guanylate cyclase activity. Circulation: Genomic and Precision Medicine, 12(8), e002472.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant NPR1 protein, GST Tag (CAT#: V2LY-0526-LY5827)

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Human Recombinant NPR1 protein, GST Tag (CAT#: V2LY-0526-LY5827)

Rat Anti-NPR1 Recombinant Antibody (CBWJN-0542) (CAT#: CBMAB-N3240-WJ)

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Mouse Anti-NPR1 Recombinant Antibody (7H7) (CAT#: CBMAB-N3238-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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