Human Recombinant NPR1 protein, GST Tag (V2LY-0526-LY5827)

Name: Human Recombinant NPR1 protein, GST Tag
SKU: V2LY-0526-LY5827
Rating: 5 (1 reviews)

See all NPR1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant NPR1 protein, GST Tag consist of Amino Acid: 495-end and predicts a molecular mass of 88 kDa.

Molecule Mass

88 kDa

Sequence

Amino Acid: 495-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tirs, NaCl, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

NATRIURETIC PEPTIDE RECEPTOR 1

Function

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Biological Process

Blood vessel diameter maintenance1 PublicationNAS:UniProtKB
Body fluid secretionManual Assertion Based On ExperimentTAS:UniProtKB
Cell surface receptor signaling pathway1 PublicationNAS:UniProtKB
cGMP biosynthetic processManual Assertion Based On ExperimentIDA:GO_Central
cGMP-mediated signalingIEA:Ensembl
Dopamine metabolic processIEA:Ensembl
Negative regulation of angiogenesisManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of cell growth1 PublicationNAS:UniProtKB
Negative regulation of smooth muscle cell proliferationIEA:Ensembl
Positive regulation of cGMP-mediated signalingIEA:Ensembl
Positive regulation of renal sodium excretionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of urine volumeManual Assertion Based On ExperimentTAS:UniProtKB
Receptor guanylyl cyclase signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of blood pressure1 PublicationNAS:UniProtKB
Regulation of vascular permeabilityManual Assertion Based On ExperimentTAS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Extracellular: 33-473
Helical: 474-494
Cytoplasmic: 495-1061

PTM

Phosphorylation of the protein kinase-like domain is required for full activation by ANP.

Sasahara, M., Kanda, M., Tanaka, C., Shimizu, D., Umeda, S., Takami, H., ... & Kodera, Y. (2024). Therapeutic antibody targeting natriuretic peptide receptor 1 inhibits gastric cancer growth via BCL‐2‐mediated intrinsic apoptosis. International Journal of Cancer, 154(7), 1272-1284.

Tokudome, T., Otani, K., Mao, Y., Jensen, L. J., Arai, Y., Miyazaki, T., ... & Nishimura, H. (2022). Endothelial natriuretic peptide receptor 1 play crucial role for acute and chronic blood pressure regulation by atrial natriuretic peptide. Hypertension, 79(7), 1409-1422.

Pandey, K. N. (2019). Genetic ablation and guanylyl cyclase/natriuretic peptide receptor-A: impact on the pathophysiology of cardiovascular dysfunction. International Journal of Molecular Sciences, 20(16), 3946.

Solinski, H. J., Dranchak, P., Oliphant, E., Gu, X., Earnest, T. W., Braisted, J., ... & Hoon, M. A. (2019). Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 11(500), eaav5464.

Periyasamy, R., Das, S., & Pandey, K. N. (2019). Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice. Peptides, 114, 17-28.

Vandenwijngaert, S., Ledsky, C. D., Lahrouchi, N., Khan, M. A., Wunderer, F., Ames, L., ... & CHARGE+ Exome Chip Blood Pressure Consortium, the CHD Exome+ Consortium, the Exome BP Consortium, the GoT2D Consortium, the T2D-GENES Consortium and the UK Biobank CardioMetabolic Consortium BP Working Group. (2019). Blood pressure-associated genetic variants in the natriuretic peptide receptor 1 gene modulate guanylate cyclase activity. Circulation: Genomic and Precision Medicine, 12(8), e002472.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant NPR1 protein, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-NPR1 Recombinant Antibody (7H7) (CAT#: CBMAB-N3238-WJ)

Rat Anti-NPR1 Recombinant Antibody (CBWJN-0542) (CAT#: CBMAB-N3240-WJ)

Mouse Anti-NPR1 Recombinant Antibody (CBWJN-1516) (CAT#: CBMAB-N3235-WJ)

Mouse Anti-NPR1 Recombinant Antibody (8H163) (CAT#: CBMAB-N3239-WJ)

Rat Anti-NPR1 Recombinant Antibody (CBWJN-1517) (CAT#: CBMAB-N3236-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry