Mouse Anti-NPS Recombinant Antibody (CBWJN-1520) (CBMAB-N3260-WJ)

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Basic Information

Host Animal
Mouse
Clone
CBWJN-1520
Application
WB, ICC, IHC-P, IHC-F, ELISA
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Neuropeptide S
Introduction
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
Entrez Gene ID
UniProt ID
Alternative Names
Neuropeptide S; Prepro-Neuropeptide S;
Function
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity).
Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
Biological Process
Neuropeptide signaling pathwayIEA:UniProtKB-KW
Positive regulation of action potentialManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of circadian sleep/wake cycle, wakefulnessIEA:Ensembl
Positive regulation of synaptic transmission, GABAergicManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of synaptic transmission, glutamatergicManual Assertion Based On ExperimentIBA:GO_Central
Visual learningIEA:Ensembl
Cellular Location
Secreted

Shirsath, K. R., Patil, V. K., Awathale, S. N., Goyal, S. N., & Nakhate, K. T. (2024). Pathophysiological and Therapeutic Implications of Neuropeptide S System in Neurological Disorders. Peptides, 171167.

Song, C., Zhu, Z. C., Liu, C. C., Yun, W. X., Wang, Z. Y., Lu, G. Y., ... & Li, F. (2024). Neuropeptide S Receptor 1 variant (I107N) regulates behavioral characteristics and NPS effect in mice in a sex-dependent manner. Neuropharmacology, 242, 109771.

Akçalı, İ., Akkan, S. S., & Bülbül, M. (2023). The regulatory role of central neuropeptide-S in locomotion. Peptides, 170, 171110.

Markiewicz-Gospodarek, A., Markiewicz, R., Dobrowolska, B., Rahnama, M., & Łoza, B. (2022). Relationship of neuropeptide S (NPS) with neurocognitive, clinical, and electrophysiological parameters of patients during structured rehabilitation therapy for schizophrenia. Journal of Clinical Medicine, 11(18), 5266.

Huang, D., Zhang, R., Gasparini, S., McDonough, M. C., Paradee, W. J., & Geerling, J. C. (2022). Neuropeptide S (NPS) neurons: Parabrachial identity and novel distributions. Journal of Comparative Neurology, 530(18), 3157-3178.

Markiewicz-Gospodarek, A., Kuszta, P., Baj, J., Dobrowolska, B., & Markiewicz, R. (2022). Can Neuropeptide S be an indicator for assessing anxiety in psychiatric disorders?. Frontiers in Public Health, 10, 872430.

Cannella, N., Borruto, A. M., Petrella, M., Micioni Di Bonaventura, M. V., Soverchia, L., Cifani, C., ... & Ubaldi, M. (2022). A Role for Neuropeptide S in Alcohol and Cocaine Seeking. Pharmaceuticals, 15(7), 800.

Botticelli, L., Micioni Di Bonaventura, E., Ubaldi, M., Ciccocioppo, R., Cifani, C., & Micioni Di Bonaventura, M. V. (2021). The Neural Network of Neuropeptide S (NPS): Implications in food intake and gastrointestinal functions. Pharmaceuticals, 14(4), 293.

Kushikata, T., Hirota, K., Saito, J., & Takekawa, D. (2021). Roles of neuropeptide S in anesthesia, analgesia, and sleep. Pharmaceuticals, 14(5), 483.

Grund, T., & Neumann, I. D. (2019). Brain neuropeptide S: via GPCR activation to a powerful neuromodulator of socio-emotional behaviors. Cell and tissue research, 375, 123-132.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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