Human NPS ELISA Kit (V2LY-0626-LY4255)

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Tested Data
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Basic Information

Sensitivity
0.0038 ng/mL
Detection Range
0.005-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
10.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Neuropeptide S
Function
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity).
Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
Biological Process
Neuropeptide signaling pathwayIEA:UniProtKB-KW
Positive regulation of action potentialManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of circadian sleep/wake cycle, wakefulnessIEA:Ensembl
Positive regulation of synaptic transmission, GABAergicManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of synaptic transmission, glutamatergicManual Assertion Based On ExperimentIBA:GO_Central
Visual learningIEA:Ensembl
Cellular Location
Secreted

Shirsath, K. R., Patil, V. K., Awathale, S. N., Goyal, S. N., & Nakhate, K. T. (2024). Pathophysiological and Therapeutic Implications of Neuropeptide S System in Neurological Disorders. Peptides, 171167.

Song, C., Zhu, Z. C., Liu, C. C., Yun, W. X., Wang, Z. Y., Lu, G. Y., ... & Li, F. (2024). Neuropeptide S Receptor 1 variant (I107N) regulates behavioral characteristics and NPS effect in mice in a sex-dependent manner. Neuropharmacology, 242, 109771.

Akçalı, İ., Akkan, S. S., & Bülbül, M. (2023). The regulatory role of central neuropeptide-S in locomotion. Peptides, 170, 171110.

Markiewicz-Gospodarek, A., Markiewicz, R., Dobrowolska, B., Rahnama, M., & Łoza, B. (2022). Relationship of neuropeptide S (NPS) with neurocognitive, clinical, and electrophysiological parameters of patients during structured rehabilitation therapy for schizophrenia. Journal of Clinical Medicine, 11(18), 5266.

Huang, D., Zhang, R., Gasparini, S., McDonough, M. C., Paradee, W. J., & Geerling, J. C. (2022). Neuropeptide S (NPS) neurons: Parabrachial identity and novel distributions. Journal of Comparative Neurology, 530(18), 3157-3178.

Markiewicz-Gospodarek, A., Kuszta, P., Baj, J., Dobrowolska, B., & Markiewicz, R. (2022). Can Neuropeptide S be an indicator for assessing anxiety in psychiatric disorders?. Frontiers in Public Health, 10, 872430.

Cannella, N., Borruto, A. M., Petrella, M., Micioni Di Bonaventura, M. V., Soverchia, L., Cifani, C., ... & Ubaldi, M. (2022). A Role for Neuropeptide S in Alcohol and Cocaine Seeking. Pharmaceuticals, 15(7), 800.

Botticelli, L., Micioni Di Bonaventura, E., Ubaldi, M., Ciccocioppo, R., Cifani, C., & Micioni Di Bonaventura, M. V. (2021). The Neural Network of Neuropeptide S (NPS): Implications in food intake and gastrointestinal functions. Pharmaceuticals, 14(4), 293.

Kushikata, T., Hirota, K., Saito, J., & Takekawa, D. (2021). Roles of neuropeptide S in anesthesia, analgesia, and sleep. Pharmaceuticals, 14(5), 483.

Grund, T., & Neumann, I. D. (2019). Brain neuropeptide S: via GPCR activation to a powerful neuromodulator of socio-emotional behaviors. Cell and tissue research, 375, 123-132.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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