NPS
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
Full Name
Neuropeptide S
Function
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity).
Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
Biological Process
Neuropeptide signaling pathwayIEA:UniProtKB-KW
Positive regulation of action potentialManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of circadian sleep/wake cycle, wakefulnessIEA:Ensembl
Positive regulation of synaptic transmission, GABAergicManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of synaptic transmission, glutamatergicManual Assertion Based On ExperimentIBA:GO_Central
Visual learningIEA:Ensembl
Positive regulation of action potentialManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of circadian sleep/wake cycle, wakefulnessIEA:Ensembl
Positive regulation of synaptic transmission, GABAergicManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of synaptic transmission, glutamatergicManual Assertion Based On ExperimentIBA:GO_Central
Visual learningIEA:Ensembl
Cellular Location
Secreted
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Anti-NPS antibodies
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CompareTarget: NPS
Sensitivity: 0.0038 ng/mL
Detection Range: 0.005-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Nps
Sensitivity: 0.00097 ng/mL
Detection Range: 0.002-0.6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Nps
Sensitivity: 0.024 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: NPS
Host: Mouse
Specificity: Rat
Clone: CBWJN-1521
Application*: WB, IC, P, IH-F, E
Target: NPS
Host: Mouse
Specificity: Human
Clone: CBWJN-1520
Application*: WB, IC, P, IH-F, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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