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Mouse Anti-NRBP1 Recombinant Antibody (7E2) (CBMAB-N3538-WJ)

This product is a Mouse antibody that recognizes NRBP1. The antibody 7E2 can be used for immunoassay techniques such as: WB, IHC, FC, IP.
See all NRBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Rat, Monkey
Clone
7E2
Antibody Isotype
IgG2b
Application
WB, IHC, FC, IP

Basic Information

Specificity
Human, Dog, Rat, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nuclear Receptor Binding Protein 1
Introduction
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.
Entrez Gene ID
Human29959
Monkey700821
Rat619579
Dog475704
UniProt ID
HumanQ9UHY1
MonkeyG7N9P3
RatQ3SWT7
DogE2REI7
Alternative Names
Nuclear Receptor Binding Protein 1; BCON3; NRBP; Myeloid Leukemia Factor 1 Adaptor Molecule; Multiple Domain Putative Nuclear Protein; Nuclear Receptor Binding Protein; Nuclear Receptor-Binding Protein; MUDPNP; MADM;
Function
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cell cortex
Endomembrane system
Cell projection, lamellipodium
Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

Zhang, Q., Fang, H., & Zhu, Z. (2023). NRBP1 modulates uric acid transporter ABCG2 expression by activating the Wnt/β-catenin pathway in HK-2 cells. Nefrología (English Edition), 43(2), 204-212.

Yang, X., Cruz, M. I., Nguyen, E. V., Huang, C., Schittenhelm, R. B., Luu, J., ... & Daly, R. J. (2023). The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer. Oncogene, 42(11), 833-847.

Mushtaq, Z., Aavula, K., Lasser, D. A., Kieweg, I. D., Lion, L. M., Kins, S., & Pielage, J. (2022). Madm/NRBP1 mediates synaptic maintenance and neurodegeneration-induced presynaptic homeostatic potentiation. Cell Reports, 41(9).

Yao, W., Cao, Q., Luo, S., He, L., Yang, C., Chen, J., ... & Zhang, J. C. (2022). Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine. Molecular psychiatry, 27(3), 1618-1629.

Du, L., Zhang, L., & Sun, F. (2022). Puerarin inhibits the progression of bladder cancer by regulating circ_0020394/miR-328-3p/NRBP1 axis. Cancer Biotherapy & Radiopharmaceuticals, 37(6), 435-450.

Ren, X., Cheng, J., Zhu, M., Chen, X., Jiang, M., Hu, X., & Lu, Y. (2022). Circular RNA circ_0062019 exerts oncogenic properties in prostate cancer via mediating miR‐1253/NRBP1 axis. Andrologia, 54(3), e14343.

Qin, L., Sun, X., Zhou, F., & Liu, C. (2021). CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1. World Journal of Surgical Oncology, 19(1), 1-14.

Yasukawa, T., Tsutsui, A., Tomomori-Sato, C., Sato, S., Saraf, A., Washburn, M. P., ... & Aso, T. (2020). NRBP1-containing CRL2/CRL4A regulates amyloid β production by targeting BRI2 and BRI3 for degradation. Cell Reports, 30(10), 3478-3491.

Hwang, J., Haque, M. A., Suzuki, H., Ten Dijke, P., & Kato, M. (2020). THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells. Biochemical and biophysical research communications, 523(2), 307-314.

Wu, Q., Zhou, X., Li, P., Wang, W., Wang, J., Tan, M., ... & Qiu, J. (2019). High NRBP1 expression promotes proliferation and correlates with poor prognosis in bladder cancer. Journal of Cancer, 10(18), 4270.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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