Human Recombinant NRBP1 protein, GST Tag (V2LY-0526-LY5848)

Name: Human Recombinant NRBP1 protein, GST Tag
SKU: V2LY-0526-LY5848
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant NRBP1 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 92 kDa.

Molecule Mass

92 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Nuclear Receptor Binding Protein 1

Function

May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.

Biological Process

Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cell cortex
Endomembrane system
Cell projection, lamellipodium
Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

Zhang, Q., Fang, H., & Zhu, Z. (2023). NRBP1 modulates uric acid transporter ABCG2 expression by activating the Wnt/β-catenin pathway in HK-2 cells. Nefrología (English Edition), 43(2), 204-212.

Yang, X., Cruz, M. I., Nguyen, E. V., Huang, C., Schittenhelm, R. B., Luu, J., ... & Daly, R. J. (2023). The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer. Oncogene, 42(11), 833-847.

Mushtaq, Z., Aavula, K., Lasser, D. A., Kieweg, I. D., Lion, L. M., Kins, S., & Pielage, J. (2022). Madm/NRBP1 mediates synaptic maintenance and neurodegeneration-induced presynaptic homeostatic potentiation. Cell Reports, 41(9).

Yao, W., Cao, Q., Luo, S., He, L., Yang, C., Chen, J., ... & Zhang, J. C. (2022). Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine. Molecular psychiatry, 27(3), 1618-1629.

Du, L., Zhang, L., & Sun, F. (2022). Puerarin inhibits the progression of bladder cancer by regulating circ_0020394/miR-328-3p/NRBP1 axis. Cancer Biotherapy & Radiopharmaceuticals, 37(6), 435-450.

Ren, X., Cheng, J., Zhu, M., Chen, X., Jiang, M., Hu, X., & Lu, Y. (2022). Circular RNA circ_0062019 exerts oncogenic properties in prostate cancer via mediating miR‐1253/NRBP1 axis. Andrologia, 54(3), e14343.

Qin, L., Sun, X., Zhou, F., & Liu, C. (2021). CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1. World Journal of Surgical Oncology, 19(1), 1-14.

Yasukawa, T., Tsutsui, A., Tomomori-Sato, C., Sato, S., Saraf, A., Washburn, M. P., ... & Aso, T. (2020). NRBP1-containing CRL2/CRL4A regulates amyloid β production by targeting BRI2 and BRI3 for degradation. Cell Reports, 30(10), 3478-3491.

Hwang, J., Haque, M. A., Suzuki, H., Ten Dijke, P., & Kato, M. (2020). THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells. Biochemical and biophysical research communications, 523(2), 307-314.

Wu, Q., Zhou, X., Li, P., Wang, W., Wang, J., Tan, M., ... & Qiu, J. (2019). High NRBP1 expression promotes proliferation and correlates with poor prognosis in bladder cancer. Journal of Cancer, 10(18), 4270.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

NRBP1 Matched Antibody Pair (819) (CAT#: APMAB-819LY)

Antibody Pairs

NRBP1 Matched Antibody Pair (819) (CAT#: APMAB-819LY)

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NRBP1 Matched Antibody Pair (819) (CAT#: APMAB-819LY)

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Isotype control

For research use only. Not intended for any clinical use.

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