Mouse Anti-NRCAM Recombinant Antibody (CBWJN-1544) (CBMAB-N3553-WJ)

Name: Mouse Anti-NRCAM Recombinant Antibody (CBWJN-1544)
SKU: CBMAB-N3553-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-1544

Application

WB, ELISA(Cap)

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Neuronal Cell Adhesion Molecule

Introduction

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Entrez Gene ID

4897

UniProt ID

Q92823

Alternative Names

Neuronal Cell Adhesion Molecule; NgCAM-Related Cell Adhesion Molecule; Neuronal Surface Protein Bravo; Ng-CAM-Related; KIAA0343; Nr-CAM; HBravo;

Function

Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

Biological Process

AngiogenesisManual Assertion Based On ExperimentIEP:UniProtKB
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Axonal fasciculation1 PublicationNAS:UniProtKB
Axonogenesis1 PublicationNAS:UniProtKB
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Central nervous system development1 PublicationNAS:UniProtKB
Clustering of voltage-gated sodium channelsManual Assertion Based On ExperimentIDA:UniProtKB
Neuron migration1 PublicationNAS:UniProtKB
Neuronal action potential propagationIEA:Ensembl
Positive regulation of neuron differentiation1 PublicationNAS:UniProtKB
Protein localizationIEA:Ensembl
Regulation of axon extension1 PublicationNAS:UniProtKB
Regulation of neuron projection developmentIEA:Ensembl
Regulation of postsynapse organizationIEA:Ensembl
Retinal ganglion cell axon guidanceIEA:Ensembl
Synapse assemblyManual Assertion Based On ExperimentTAS:UniProtKB

Topology

Extracellular: 25-1167
Helical: 25-1167
Cytoplasmic: 1191-1304

He, L., Guo, H., Wang, H., Zhu, K., Li, D., Zhang, C., ... & Yang, J. J. (2024). Rbfox1 regulates alternative splicing of Nrcam in primary sensory neurons to mediate peripheral nerve injury-induced neuropathic pain. Neurotherapeutics, 21(1), e00309.

Zhou, L., He, L., Liu, C. H., Qiu, H., Zheng, L., Sample, K. M., ... & Tang, H. (2023). Liver cancer stem cell dissemination and metastasis: uncovering the role of NRCAM in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 42(1), 311.

Sannes, A. C., Christensen, J. O., Nielsen, M. B., & Gjerstad, J. (2023). Stress-induced headache in the general working population is moderated by the NRCAM rs2300043 genotype. Scandinavian Journal of Pain, 23(2), 326-332.

Olsen, M. B., Sannes, A. C., Yang, K., Nielsen, M. B., Einarsen, S. V., Christensen, J. O., ... & Gjerstad, J. (2022). Mapping of pituitary stress-induced gene regulation connects Nrcam to negative emotions. Iscience, 25(9).

Huang, F. J., Liu, Y. L., Wang, J., Zhou, Y. Y., Zhao, S. Y., & Qin, G. J. (2022). LncRNA RUNX1-IT1 affects the differentiation of Th1 cells by regulating NrCAM transcription in Graves’ disease. Cell Cycle, 21(9), 921-933.

Moore, A., Chinnaiya, K., Kim, D. W., Brown, S., Stewart, I., Robins, S., ... & Placzek, M. (2022). Loss of Function of the neural cell adhesion molecule NrCAM regulates differentiation, proliferation and neurogenesis in early postnatal hypothalamic tanycytes. Frontiers in Neuroscience, 16, 832961.

Cheng, Y., Xie, L., Xu, Z., Hao, M., Yang, B., Shan, W., ... & Chen, X. (2022). NrCAM secreted by endometrial stromal cells enhances the progestin sensitivity of endometrial cancer cells through epigenetic modulation of PRB. Cancer Gene Therapy, 29(10), 1452-1462.

Liang, L., Wu, S., Lin, C., Chang, Y. J., & Tao, Y. X. (2020). Alternative splicing of Nrcam gene in dorsal root ganglion contributes to neuropathic pain. The Journal of Pain, 21(7-8), 892-904.

Mohan, V., Sullivan, C. S., Guo, J., Wade, S. D., Majumder, S., Agarwal, A., ... & Maness, P. F. (2019). Temporal regulation of dendritic spines through NrCAM-Semaphorin3F receptor signaling in developing cortical pyramidal neurons. Cerebral Cortex, 29(3), 963-977.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
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Isotype control

For research use only. Not intended for any clinical use.

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