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NRCAM

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Full Name
Neuronal Cell Adhesion Molecule
Function
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
Biological Process
AngiogenesisManual Assertion Based On ExperimentIEP:UniProtKB
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Axonal fasciculation1 PublicationNAS:UniProtKB
Axonogenesis1 PublicationNAS:UniProtKB
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Central nervous system development1 PublicationNAS:UniProtKB
Clustering of voltage-gated sodium channelsManual Assertion Based On ExperimentIDA:UniProtKB
Neuron migration1 PublicationNAS:UniProtKB
Neuronal action potential propagationIEA:Ensembl
Positive regulation of neuron differentiation1 PublicationNAS:UniProtKB
Protein localizationIEA:Ensembl
Regulation of axon extension1 PublicationNAS:UniProtKB
Regulation of neuron projection developmentIEA:Ensembl
Regulation of postsynapse organizationIEA:Ensembl
Retinal ganglion cell axon guidanceIEA:Ensembl
Synapse assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Topology
Extracellular: 25-1167
Helical: 25-1167
Cytoplasmic: 1191-1304

Anti-NRCAM antibodies

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Target: NRCAM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D2H1T
Application*: WB
Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJN-0677
Application*: WB, P
Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H74
Application*: E, WB
Target: NRCAM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7D8C5
Application*: WB, E, IF
Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJN-0234
Application*: WB
Target: NRCAM
Host: Mouse
Specificity: Human
Clone: CBWJN-0217
Application*: E, IC, WB
Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 8E25
Application*: P, WB
Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1544
Application*: WB, EC
Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1543
Application*: WB
Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat
Clone: S364-51
Application*: WB, IC
Target: NRCAM
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: S36451
Application*: IC, IF, WB
Target: NRCAM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: 23A7
Application*: IH, IP, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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