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NRCAM

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Full Name
Neuronal Cell Adhesion Molecule
Function
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
Biological Process
AngiogenesisManual Assertion Based On ExperimentIEP:UniProtKB
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Axonal fasciculation1 PublicationNAS:UniProtKB
Axonogenesis1 PublicationNAS:UniProtKB
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Central nervous system development1 PublicationNAS:UniProtKB
Clustering of voltage-gated sodium channelsManual Assertion Based On ExperimentIDA:UniProtKB
Neuron migration1 PublicationNAS:UniProtKB
Neuronal action potential propagationIEA:Ensembl
Positive regulation of neuron differentiation1 PublicationNAS:UniProtKB
Protein localizationIEA:Ensembl
Regulation of axon extension1 PublicationNAS:UniProtKB
Regulation of neuron projection developmentIEA:Ensembl
Regulation of postsynapse organizationIEA:Ensembl
Retinal ganglion cell axon guidanceIEA:Ensembl
Synapse assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Topology
Extracellular: 25-1167
Helical: 25-1167
Cytoplasmic: 1191-1304
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Anti-NRCAM antibodies

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Mouse Anti-NRCAM Recombinant Antibody (23A7) (CBMAB-0104-CN)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: 23A7
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-NRCAM Recombinant Antibody (CBT3974) (V2LY-0625-LY17)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3974
Application*: IC
Datasheet SDS

Rabbit Anti-NRCAM Recombinant Antibody (D2H1T) (CBMAB-CP1763-LY)

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Target: NRCAM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D2H1T
Application*: WB
Datasheet SDS

Mouse Anti-NRCAM Recombinant Antibody (CBWJN-0677) (CBMAB-N3560-WJ)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJN-0677
Application*: WB, P
Datasheet SDS

Mouse Anti-NRCAM Recombinant Antibody (7H74) (CBMAB-N3558-WJ)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H74
Application*: E, WB
Datasheet SDS

Mouse Anti-NRCAM Recombinant Antibody (7D8C5) (CBMAB-N3557-WJ)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7D8C5
Application*: WB, E, IF
Datasheet SDS

Mouse Anti-NRCAM Recombinant Antibody (CBWJN-0234) (CBMAB-N3556-WJ)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJN-0234
Application*: WB
Datasheet SDS

Mouse Anti-NRCAM Recombinant Antibody (CBWJN-0217) (CBMAB-N3555-WJ)

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Target: NRCAM
Host: Mouse
Specificity: Human
Clone: CBWJN-0217
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-NRCAM Recombinant Antibody (8E25) (CBMAB-N3554-WJ)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 8E25
Application*: P, WB
Datasheet SDS

Mouse Anti-NRCAM Recombinant Antibody (CBWJN-1544) (CBMAB-N3553-WJ)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1544
Application*: WB, EC
Datasheet SDS

Mouse Anti-NRCAM Recombinant Antibody (CBWJN-1543) (CBMAB-N3552-WJ)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1543
Application*: WB
Datasheet SDS

Mouse Anti-NRCAM Recombinant Antibody (S364-51) (CBMAB-N0521-WJ)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat
Clone: S364-51
Application*: WB, IC
Datasheet SDS

Mouse Anti-NRCAM Monoclonal Antibody (S36451) (CBMAB-1431-YC)

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Target: NRCAM
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: S36451
Application*: IC, IF, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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