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Mouse Anti-NRCAM Monoclonal Antibody (S36451) (CBMAB-1431-YC)

Provided herein is a mouse monoclonal antibody against Mouse NRCAM. The antibody, clone S36451, can be used for immunoassay techniques, such as ICC, IF and WB.
See all NRCAM antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
S36451
Antibody Isotype
IgG
Application
ICC, IF, WB

Basic Information

Immunogen
Fusion protein corresponding to Mouse NrCAM aa 30-845
Specificity
Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuronal Cell Adhesion Molecule
Introduction
NRCAM is a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. NRCAM is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. NRCAM is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration.
Entrez Gene ID
Mouse319504
Rat497815
UniProt ID
MouseQ810U4
RatP97686
Alternative Names
Bravo; mKIAA0343; C030017F07Rik; C130076O07Rik
Function
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
Biological Process
AngiogenesisManual Assertion Based On ExperimentIEP:UniProtKB
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Axonal fasciculation1 PublicationNAS:UniProtKB
Axonogenesis1 PublicationNAS:UniProtKB
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Central nervous system development1 PublicationNAS:UniProtKB
Clustering of voltage-gated sodium channelsManual Assertion Based On ExperimentIDA:UniProtKB
Neuron migration1 PublicationNAS:UniProtKB
Neuronal action potential propagationIEA:Ensembl
Positive regulation of neuron differentiation1 PublicationNAS:UniProtKB
Protein localizationIEA:Ensembl
Regulation of axon extension1 PublicationNAS:UniProtKB
Regulation of neuron projection developmentIEA:Ensembl
Regulation of postsynapse organizationIEA:Ensembl
Retinal ganglion cell axon guidanceIEA:Ensembl
Synapse assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Topology
Extracellular: 25-1167
Helical: 25-1167
Cytoplasmic: 1191-1304
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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