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Mouse Anti-NRN1 Recombinant Antibody (CBWJN-0224) (CBMAB-N3605-WJ)

This product is a Mouse antibody that recognizes NRN1. The antibody CBWJN-0224 can be used for immunoassay techniques such as: WB.
See all NRN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0224
Antibody Isotype
IgG2
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuritin 1
Introduction
This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Entrez Gene ID
51299
UniProt ID
Q9NPD7
Alternative Names
Neuritin 1; NRN; DJ380B8.2; Neuritin;
Function
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
Biological Process
Neuron projection extensionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cell junction, synapse

Hameed, S. S., Bodi, N., & Sharma, T. P. (2023). Neuritin 1: A therapy to promote retinal ganglion cell survival in an ex-vivo pressurized human ocular system. Investigative Ophthalmology & Visual Science, 64(8), 1899-1899.

Hurst, C., Pugh, D. A., Abreha, M. H., Duong, D. M., Dammer, E. B., Bennett, D. A., ... & Seyfried, N. T. (2023). Integrated proteomics to understand the role of neuritin (NRN1) as a mediator of cognitive resilience to Alzheimer’s disease. Molecular & Cellular Proteomics, 22(5).

Hameed, S. S., Miller, R. C., & Sharma, T. P. (2022). Human neuritin 1: Therapeutic Strategy for Juvenile Open-Angle Glaucoma. Investigative Ophthalmology & Visual Science, 63(7), 1621-A0444.

Hurst, C., Pugh, D. A., Abreha, M. H., Duong, D. M., Dammer, E. B., Bennett, D. A., ... & Seyfried, N. T. (2022). Integrated Proteomics Identifies Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer’s Disease. bioRxiv, 2022-06.

Wan, K., Mao, F., Li, Q., Wang, L., Wei, Z., Wang, P., ... & Gan, S. (2021). Neuritin-overexpressing transgenic mice demonstrate enhanced neuroregeneration capacity and improved spatial learning and memory recovery after ischemia-reperfusion injury. Aging (Albany NY), 13(2), 2681.

Lee, S. H., Kim, N. S., Choi, M., Ko, S. Y., Wang, S. E., Jo, H. R., ... & Son, H. (2021). LGI1 governs neuritin-mediated resilience to chronic stress. Neurobiology of Stress, 15, 100373.

Huang, T., Li, H., Zhang, S., Liu, F., Wang, D., & Xu, J. (2021). Nrn1 overexpression attenuates retinal ganglion cell apoptosis, promotes axonal regeneration, and improves visual function following optic nerve crush in rats. Journal of Molecular Neuroscience, 71, 66-79.

Lu, J., Li, Z., Zhao, Q., Liu, D., & Mei, Y. A. (2021). Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice. Neurobiology of Disease, 156, 105407.

Rahmawati, E., Yang, W. C. V., Lei, Y. P., Maurya, P. K., Chen, H. W., & Tzeng, C. R. (2019). Decreased level of neurotrophic factor neuritin 1 in women with ovarian endometriosis after receiving gonadotropin-releasing hormone agonist treatment. International journal of molecular sciences, 20(18), 4352.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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