Human NRN1 ELISA Kit (V2LY-0626-LY4942)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0096 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
15.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Neuritin 1
Function
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
Biological Process
Neuron projection extensionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cell junction, synapse

Hameed, S. S., Bodi, N., & Sharma, T. P. (2023). Neuritin 1: A therapy to promote retinal ganglion cell survival in an ex-vivo pressurized human ocular system. Investigative Ophthalmology & Visual Science, 64(8), 1899-1899.

Hurst, C., Pugh, D. A., Abreha, M. H., Duong, D. M., Dammer, E. B., Bennett, D. A., ... & Seyfried, N. T. (2023). Integrated proteomics to understand the role of neuritin (NRN1) as a mediator of cognitive resilience to Alzheimer’s disease. Molecular & Cellular Proteomics, 22(5).

Hameed, S. S., Miller, R. C., & Sharma, T. P. (2022). Human neuritin 1: Therapeutic Strategy for Juvenile Open-Angle Glaucoma. Investigative Ophthalmology & Visual Science, 63(7), 1621-A0444.

Hurst, C., Pugh, D. A., Abreha, M. H., Duong, D. M., Dammer, E. B., Bennett, D. A., ... & Seyfried, N. T. (2022). Integrated Proteomics Identifies Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer’s Disease. bioRxiv, 2022-06.

Wan, K., Mao, F., Li, Q., Wang, L., Wei, Z., Wang, P., ... & Gan, S. (2021). Neuritin-overexpressing transgenic mice demonstrate enhanced neuroregeneration capacity and improved spatial learning and memory recovery after ischemia-reperfusion injury. Aging (Albany NY), 13(2), 2681.

Lee, S. H., Kim, N. S., Choi, M., Ko, S. Y., Wang, S. E., Jo, H. R., ... & Son, H. (2021). LGI1 governs neuritin-mediated resilience to chronic stress. Neurobiology of Stress, 15, 100373.

Huang, T., Li, H., Zhang, S., Liu, F., Wang, D., & Xu, J. (2021). Nrn1 overexpression attenuates retinal ganglion cell apoptosis, promotes axonal regeneration, and improves visual function following optic nerve crush in rats. Journal of Molecular Neuroscience, 71, 66-79.

Lu, J., Li, Z., Zhao, Q., Liu, D., & Mei, Y. A. (2021). Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice. Neurobiology of Disease, 156, 105407.

Rahmawati, E., Yang, W. C. V., Lei, Y. P., Maurya, P. K., Chen, H. W., & Tzeng, C. R. (2019). Decreased level of neurotrophic factor neuritin 1 in women with ovarian endometriosis after receiving gonadotropin-releasing hormone agonist treatment. International journal of molecular sciences, 20(18), 4352.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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