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Mouse Anti-NUDT12 Recombinant Antibody (V2-178325) (CBMAB-N3874-WJ)

This product is a Mouse antibody that recognizes NUDT12. The antibody 1A2 can be used for immunoassay techniques such as: WB, IHC .
See all NUDT12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-178325
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 12
Introduction
Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
83594
UniProt ID
Q9BQG2
Alternative Names
Nudix Hydrolase 12; EC 3.6.1.22; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 12; Nucleoside Diphosphate Linked Moiety X-Type Motif 12; Nucleoside Diphosphate-Linked Moiety X Motif 12; Nudix Motif 12;
Function
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:31875550).
The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919).
Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919).
Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (PubMed:12790796).
May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (PubMed:12790796).
Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity).
Biological Process
Circadian regulation of gene expressionISS:UniProtKB
Methylguanosine-cap decappingManual Assertion Based On ExperimentIDA:UniProtKB
mRNA catabolic processISS:UniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
NAD catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
NAD-cap decappingManual Assertion Based On ExperimentIDA:UniProtKB
NADH metabolic processManual Assertion Based On ExperimentIBA:GO_Central
NADP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Peroxisome
Cytoplasmic granule
Localizes to cytoplasmic granules in the presence of BLMH.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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