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NUDT12

Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM
Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 12
Function
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:31875550).
The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919).
Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919).
Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (PubMed:12790796).
May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (PubMed:12790796).
Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity).
Biological Process
Circadian regulation of gene expressionISS:UniProtKB
Methylguanosine-cap decappingManual Assertion Based On ExperimentIDA:UniProtKB
mRNA catabolic processISS:UniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
NAD catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
NAD-cap decappingManual Assertion Based On ExperimentIDA:UniProtKB
NADH metabolic processManual Assertion Based On ExperimentIBA:GO_Central
NADP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Peroxisome
Cytoplasmic granule
Localizes to cytoplasmic granules in the presence of BLMH.

Anti-NUDT12 antibodies

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Target: NUDT12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7C3
Application*: WB
Target: NUDT12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6F1
Application*: WB, IH
Target: NUDT12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B6
Application*: WB, IH
Target: NUDT12
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 3F7
Application*: E, WB
Target: NUDT12
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2G2
Application*: WB, IH
Target: NUDT12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178325
Application*: WB, IH
Target: NUDT12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3E7
Application*: WB, IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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