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Mouse Anti-NVL Recombinant Antibody (3D10) (CBMAB-N4051-WJ)

This product is a Mouse antibody that recognizes NVL. The antibody 3D10 can be used for immunoassay techniques such as: ELISA, WB.
See all NVL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3D10
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nuclear VCP-Like
Introduction
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]
Entrez Gene ID
4931
UniProt ID
O15381
Alternative Names
Nuclear VCP-Like; Nuclear Valosin-Containing Protein-Like; Nuclear VCP-Like Protein; NVLp; NVL2;
Function
Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966).
Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824).
Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651).
Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).
Biological Process
Positive regulation of protein bindingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of telomerase activityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein localization to nucleolusManual Assertion Based On ExperimentIDA:UniProtKB
Ribosomal large subunit biogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Ribosome biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
rRNA processingManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Isoform 2
Nucleus, nucleoplasm
Isoform 1
Nucleus, nucleolus
Nucleus, nucleoplasm
Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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